Matches in SemOpenAlex for { <https://semopenalex.org/work/W1577546429> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W1577546429 endingPage "97" @default.
- W1577546429 startingPage "95" @default.
- W1577546429 abstract "Autoimmune thyroid disease (AITD) has been considered the prototypical and the most prevalent organ-specific autoimmune disorder, affecting 2% to 5% of iodine-sufficient population (1). This condition encompasses a clinical-pathological spectrum of different phenotypes varying from hyperthyroidism in Graves’ disease to hypothyroidism in Hashimoto’s thyroiditis, probably representing the net effect of a complex mechanism causing break of tolerance to thyroid proteins through interac tion between genetic susceptibility and environmental triggers (2-4). The rational for this theory is based on both family studies and in twins based studies showing respectively a higher frequency of AITD in the relatives of an affected individual and a higher but not complete concordance among identical twins (5). Several genes have been associated with AITD, including immune-response genes (HLADRA II and CD40), T-cell regulation genes (CTLA4, PTPN22, CD25), and thyroid-specific antigens genes (TG, and TSHR). However, these genes together pro bably do not confer more than about 10% of the genetic susceptibility for AITD (6). In other words, there is no single or dominant gene strong enough to confer major susceptibility to AITD. Thus, the disease seems likely to result from the combined effect of multiple genes (2-6)." @default.
- W1577546429 created "2016-06-24" @default.
- W1577546429 creator A5042776454 @default.
- W1577546429 date "2015-04-01" @default.
- W1577546429 modified "2023-09-26" @default.
- W1577546429 title "Autoimmune thyroid disease: What secrets we still need to unravel?" @default.
- W1577546429 cites W1898593257 @default.
- W1577546429 cites W1971666258 @default.
- W1577546429 cites W1973444979 @default.
- W1577546429 cites W1978758068 @default.
- W1577546429 cites W1980890651 @default.
- W1577546429 cites W1992215935 @default.
- W1577546429 cites W1992560150 @default.
- W1577546429 cites W2011189236 @default.
- W1577546429 cites W2018924436 @default.
- W1577546429 cites W2042035964 @default.
- W1577546429 cites W2068040418 @default.
- W1577546429 cites W2084311281 @default.
- W1577546429 cites W2096939410 @default.
- W1577546429 cites W2112370458 @default.
- W1577546429 cites W2134918190 @default.
- W1577546429 cites W2140884595 @default.
- W1577546429 cites W2145425388 @default.
- W1577546429 cites W2168062111 @default.
- W1577546429 cites W2169347370 @default.
- W1577546429 doi "https://doi.org/10.1590/2359-3997000000019" @default.
- W1577546429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25993669" @default.
- W1577546429 hasPublicationYear "2015" @default.
- W1577546429 type Work @default.
- W1577546429 sameAs 1577546429 @default.
- W1577546429 citedByCount "1" @default.
- W1577546429 countsByYear W15775464292018 @default.
- W1577546429 crossrefType "journal-article" @default.
- W1577546429 hasAuthorship W1577546429A5042776454 @default.
- W1577546429 hasBestOaLocation W15775464291 @default.
- W1577546429 hasConcept C126322002 @default.
- W1577546429 hasConcept C142724271 @default.
- W1577546429 hasConcept C2779075594 @default.
- W1577546429 hasConcept C2779134260 @default.
- W1577546429 hasConcept C2780176905 @default.
- W1577546429 hasConcept C526584372 @default.
- W1577546429 hasConcept C71924100 @default.
- W1577546429 hasConceptScore W1577546429C126322002 @default.
- W1577546429 hasConceptScore W1577546429C142724271 @default.
- W1577546429 hasConceptScore W1577546429C2779075594 @default.
- W1577546429 hasConceptScore W1577546429C2779134260 @default.
- W1577546429 hasConceptScore W1577546429C2780176905 @default.
- W1577546429 hasConceptScore W1577546429C526584372 @default.
- W1577546429 hasConceptScore W1577546429C71924100 @default.
- W1577546429 hasIssue "2" @default.
- W1577546429 hasLocation W15775464291 @default.
- W1577546429 hasLocation W15775464292 @default.
- W1577546429 hasOpenAccess W1577546429 @default.
- W1577546429 hasPrimaryLocation W15775464291 @default.
- W1577546429 hasRelatedWork W1999494565 @default.
- W1577546429 hasRelatedWork W2031790021 @default.
- W1577546429 hasRelatedWork W2033506857 @default.
- W1577546429 hasRelatedWork W2040375537 @default.
- W1577546429 hasRelatedWork W2153850609 @default.
- W1577546429 hasRelatedWork W2744903379 @default.
- W1577546429 hasRelatedWork W3031785252 @default.
- W1577546429 hasRelatedWork W3144195964 @default.
- W1577546429 hasRelatedWork W3201438093 @default.
- W1577546429 hasRelatedWork W96096646 @default.
- W1577546429 hasVolume "59" @default.
- W1577546429 isParatext "false" @default.
- W1577546429 isRetracted "false" @default.
- W1577546429 magId "1577546429" @default.
- W1577546429 workType "article" @default.