FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1577580829> ?p ?o ?g. }

• W1577580829 endingPage "244" @default.
• W1577580829 startingPage "228" @default.
• W1577580829 abstract "Synthetic amorphous silica nanomaterials (SAS) are extensively used in food and tire industries. In many industrial processes, SAS may become aerosolized and lead to occupational exposure of workers through inhalation in particular. However, little is known about the in vivo genotoxicity of these particulate materials. To gain insight into the toxicological properties of four SAS (NM-200, NM-201, NM-202, and NM-203), rats are treated with three consecutive intratracheal instillations of 3, 6, or 12 mg/kg of SAS at 48, 24, and 3 hrs prior to tissue collection (cumulative doses of 9, 18, and 36 mg/kg). Deoxyribonucleic acid (DNA) damage was assessed using erythrocyte micronucleus test and the standard and Fpg-modified comet assays on cells from bronchoalveolar lavage fluid (BALF), lung, blood, spleen, liver, bone marrow, and kidney. Although all of the SAS caused increased dose-dependent changes in lung inflammation as demonstrated by BALF neutrophilia, they did not induce any significant DNA damage. As the amount of SAS reaching the blood stream and subsequently the internal organs is probably to be low following intratracheal instillation, an additional experiment was performed with NM-203. Rats received three consecutive intravenous injections of 5, 10, or 20 mg/kg of SAS at 48, 24, and 3 hrs prior to tissue collection. Despite the hepatotoxicity, thrombocytopenia, and even animal death induced by this nanomaterial, no significant increase in DNA damage or micronucleus frequency was observed in SAS-exposed animals. It was concluded that under experimental conditions, SAS induced obvious toxic effects but did cause any genotoxicity following intratracheal instillation and intravenous injection. Environ. Mol. Mutagen. 56:228–244, 2015. © 2014 Wiley Periodicals, Inc." @default.
• W1577580829 created "2016-06-24" @default.
• W1577580829 creator A5007963998 @default.
• W1577580829 creator A5037839606 @default.
• W1577580829 creator A5042633967 @default.
• W1577580829 creator A5045486097 @default.
• W1577580829 creator A5060305851 @default.
• W1577580829 creator A5064665895 @default.
• W1577580829 creator A5072841617 @default.
• W1577580829 creator A5072990438 @default.
• W1577580829 creator A5075976588 @default.
• W1577580829 creator A5076571677 @default.
• W1577580829 creator A5080464412 @default.
• W1577580829 creator A5082287631 @default.
• W1577580829 date "2014-11-28" @default.
• W1577580829 modified "2023-10-13" @default.
• W1577580829 title "Genotoxicity of synthetic amorphous silica nanoparticles in rats following short-term exposure, part 2: Intratracheal instillation and intravenous injection" @default.
• W1577580829 cites W1965987889 @default.
• W1577580829 cites W1968749227 @default.
• W1577580829 cites W1988195589 @default.
• W1577580829 cites W2004070825 @default.
• W1577580829 cites W2006923555 @default.
• W1577580829 cites W2009077052 @default.
• W1577580829 cites W2010276640 @default.
• W1577580829 cites W2013934383 @default.
• W1577580829 cites W2019003182 @default.
• W1577580829 cites W2048788248 @default.
• W1577580829 cites W2063578372 @default.
• W1577580829 cites W2072760187 @default.
• W1577580829 cites W2072778949 @default.
• W1577580829 cites W2078055912 @default.
• W1577580829 cites W2082093974 @default.
• W1577580829 cites W2090051810 @default.
• W1577580829 cites W2098100151 @default.
• W1577580829 cites W2114376993 @default.
• W1577580829 cites W2123745142 @default.
• W1577580829 cites W2124676127 @default.
• W1577580829 cites W2124961458 @default.
• W1577580829 cites W2127343735 @default.
• W1577580829 cites W2129746461 @default.
• W1577580829 cites W2137098239 @default.
• W1577580829 cites W2142987561 @default.
• W1577580829 cites W2145187722 @default.
• W1577580829 cites W2160027607 @default.
• W1577580829 cites W2161940948 @default.
• W1577580829 cites W2170632276 @default.
• W1577580829 cites W4254257436 @default.
• W1577580829 doi "https://doi.org/10.1002/em.21928" @default.
• W1577580829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25451515" @default.
• W1577580829 hasPublicationYear "2014" @default.
• W1577580829 type Work @default.
• W1577580829 sameAs 1577580829 @default.
• W1577580829 citedByCount "43" @default.
• W1577580829 countsByYear W15775808292014 @default.
• W1577580829 countsByYear W15775808292015 @default.
• W1577580829 countsByYear W15775808292016 @default.
• W1577580829 countsByYear W15775808292017 @default.
• W1577580829 countsByYear W15775808292018 @default.
• W1577580829 countsByYear W15775808292019 @default.
• W1577580829 countsByYear W15775808292020 @default.
• W1577580829 countsByYear W15775808292021 @default.
• W1577580829 countsByYear W15775808292022 @default.
• W1577580829 countsByYear W15775808292023 @default.
• W1577580829 crossrefType "journal-article" @default.
• W1577580829 hasAuthorship W1577580829A5007963998 @default.
• W1577580829 hasAuthorship W1577580829A5037839606 @default.
• W1577580829 hasAuthorship W1577580829A5042633967 @default.
• W1577580829 hasAuthorship W1577580829A5045486097 @default.
• W1577580829 hasAuthorship W1577580829A5060305851 @default.
• W1577580829 hasAuthorship W1577580829A5064665895 @default.
• W1577580829 hasAuthorship W1577580829A5072841617 @default.
• W1577580829 hasAuthorship W1577580829A5072990438 @default.
• W1577580829 hasAuthorship W1577580829A5075976588 @default.
• W1577580829 hasAuthorship W1577580829A5076571677 @default.
• W1577580829 hasAuthorship W1577580829A5080464412 @default.
• W1577580829 hasAuthorship W1577580829A5082287631 @default.
• W1577580829 hasConcept C126322002 @default.
• W1577580829 hasConcept C143425029 @default.
• W1577580829 hasConcept C150903083 @default.
• W1577580829 hasConcept C16685009 @default.
• W1577580829 hasConcept C185592680 @default.
• W1577580829 hasConcept C203014093 @default.
• W1577580829 hasConcept C207001950 @default.
• W1577580829 hasConcept C2776954882 @default.
• W1577580829 hasConcept C2777714996 @default.
• W1577580829 hasConcept C2777802486 @default.
• W1577580829 hasConcept C2777961210 @default.
• W1577580829 hasConcept C2778959862 @default.
• W1577580829 hasConcept C2779078736 @default.
• W1577580829 hasConcept C2779777708 @default.
• W1577580829 hasConcept C2780358455 @default.
• W1577580829 hasConcept C2780931953 @default.
• W1577580829 hasConcept C29730261 @default.
• W1577580829 hasConcept C33070731 @default.
• W1577580829 hasConcept C36681516 @default.
• W1577580829 hasConcept C42219234 @default.
• W1577580829 hasConcept C45080847 @default.
• W1577580829 hasConcept C552990157 @default.

• next