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- W1577644872 abstract "Double‐stranded endonuclease activity was demonstrated for the first time in the excretory/secretory (ES) products of a parasitic nematode, Trichinella spiralis , which can reorganize host muscle cells. The endonuclease introduced double‐stranded breaks to the native DNA. The ES double‐stranded endonuclease(s) was sequence nonspecific, with a pH optimum below 6, and required divalent cations as a cofactor. Its activity was inhibited by the Zn 2+ ion. It was detected mainly in the ES products of the infective‐stage larvae of T. spiralis collected at 37 °C and was present in much smaller amounts in samples collected at 43 °C and in the products of T. pseudospiralis , a nonencapsulated species. The activity of endonuclease was blocked by antibodies against ES products. Zymographic analysis showed that the endonuclease activity was associated with at least three molecular forms, designated ≈ 25, 30 and 58 kDa, respectively." @default.
- W1577644872 created "2016-06-24" @default.
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- W1577644872 date "1999-03-01" @default.
- W1577644872 modified "2023-10-17" @default.
- W1577644872 title "Characterization of endonuclease activity from excretory/secretory products of a parasitic nematode, Trichinella spiralis" @default.
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- W1577644872 doi "https://doi.org/10.1046/j.1432-1327.1999.00174.x" @default.
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