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- W1577705009 abstract "Rheumatoid arthritis (RA) is the most common form of inflammatory arthritis affecting approximately 0.5 to 1% of the population. It follows a progressive course with evidence of structural joint damage occurring as early as 4 weeks after the onset of symptoms and usually gets fully established by 2 years in untreated patients. Based on this observation current treatment guidelines emphasize the early use of disease-modifying anti-rheumatic drugs (DMARDs) a class of therapeutic agents that have the potential to minimize or prevent joint damage. However most of the current DMARDs show loss of efficacy with time and/or development of serious adverse effects. There is therefore a need for newer DMARDs with better efficacy and a better safety profile. Leflunomide (active metabolite A77 1726) is one such new drug with novel immunomodulatory and anti-inflammatory properties that has shown promising results in terms of efficacy and safety for the treatment of this crippling autoimmune disease and is a welcome addition to the roster of anti-rheumatoid drugs. (excerpt)" @default.
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- W1577705009 date "2004-07-06" @default.
- W1577705009 modified "2023-09-23" @default.
- W1577705009 title "Leflunomide: a novel disease modifying anti-rheumatic drug." @default.
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