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- W1577737072 abstract "Abstract Neonatal immaturity of the immune system is currently believed to generally limit the induction of immune responses to vaccine Ags and to skew them toward type 2 responses. We demonstrated here that Bordetella pertussis infection in very young infants (median, 2 mo old) as well as the first administration of whole-cell pertussis vaccine induces B. pertussis Ag-specific IFN-γ secretion by the PBMC of these infants. IFN-γ was secreted by both CD4+ and CD8+ T lymphocytes, and the levels of Ag-induced IFN-γ secretion did not correlate with the age of the infants. Appearance of the specific Th-1 cell-mediated immunity was accompanied by a general shift of the cytokine secretion profile of these infants toward a stronger Th1 profile, as evidenced by the response to a polyclonal stimulation. We conclude that the immune system of 2-mo-old infants is developmentally mature enough to develop Th1 responses in vivo upon infection by B. pertussis or vaccination with whole-cell pertussis vaccines." @default.
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- W1577737072 date "2003-02-01" @default.
- W1577737072 modified "2023-10-16" @default.
- W1577737072 title "<i>Bordetella pertussis</i> Infection in 2-Month-Old Infants Promotes Type 1 T Cell Responses" @default.
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- W1577737072 doi "https://doi.org/10.4049/jimmunol.170.3.1504" @default.
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