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• W1577776864 abstract "The close association between adult T-cell leukemia (ATL) and human T-cell leukemia virus type I (HTLV-I) has been established. Nevertheless, the mechanism of progression of ATL by HTLV-I infection is still uncertain, because the virus contains no typical oncogene and no significant expression of the viral RNA has been generally found. I propose a model of leukemogenic process in ATL based on our cytogenetic data and molecular results in the literature. It seems that the rearrangement of some proto-oncogene and alpha-chain gene of the T-cell antigen receptor (TCR-alpha) is necessary for the development to overt ATL. A deficiency in the rearrangement of proto-oncogene to TCR-alpha may result in only a minor proliferation of abnormal lymphocytes and remain in the preleukemic state of ATL or in the HTLV-I carrier state." @default.
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• W1577776864 date "1991-01-01" @default.
• W1577776864 modified "2023-09-26" @default.
• W1577776864 title "Cytogenetic implication in adult T-cell leukemia" @default.
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• W1577776864 doi "https://doi.org/10.1016/0165-4608(91)90019-q" @default.
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