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• W1577862558 abstract "Chronic lymphocytic leukemia (CLL) is a hematological malignancy with significant clinical heterogeneity, due in part to the genetic alterations that leukemic cells present in each patient (Chiorazzi et al, 2005). CLL has a highly variable clinical course. Traditionally, it has been considered that about one-third of patients will never require treatment, as they will have prolonged survival and they will die from causes unrelated to the disease. In another third of cases, after an indolent phase disease progression occurs. In the remaining third of patients early treatment is required because of the aggressiveness of the disorder. However, due to the routine performance of blood counts in the population, the number of asymptomatic patients is increasing and, conversely, those who require initial treatment account for fewer than 15% of cases (Hernandez et al, 2010). Since the first descriptions of the disease, researchers have attempted to establish prognostic factors with which to make a risk assessment of disease progression and probability of death. The ultimate aim is to try and apply a targeted and early treatment that increases overall survival and quality of life in patients with more aggressive forms, and to determine reliably the cases who do not need further treatment. (Dighiero & Hamblin, 2008)." @default.
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• W1577862558 date "2012-02-10" @default.
• W1577862558 modified "2023-10-01" @default.
• W1577862558 title "Prognostic Factors in Chronic Lymphoid Leukemia and Identification of New Clinically Relevant Molecular Markers" @default.
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• W1577862558 doi "https://doi.org/10.5772/27108" @default.
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