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• W1577893399 abstract "The purine nucleoside analog 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) is a selective inhibitor of transcription by RNA polymerase II. Although a wealth of in vivo studies have suggested that DRB inhibits transcription by enhancing the premature termination of elongating polymerase molecules, in vitro studies to date have been interpreted to suggest that DRB acts at the level of transcription initiation. We have analyzed the mechanism of DRB-mediated transcription inhibition in vitro both in HeLa whole cell extracts and in a partially purified transcription system. The results indicate that the extent to which DRB inhibits the synthesis of a RNA transcript is directly proportional to its length. For example, DRB was found to preferentially inhibit transcription in vitro of promoter-distal relative to promoter-proximal portions of the adenovirus major late transcription unit. A factor potentially involved in mediating this inhibitory effect is identified. We conclude that the mechanism of DRB inhibition of transcription in vivo and in vitro are similar." @default.
• W1577893399 created "2016-06-24" @default.
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• W1577893399 creator A5022945869 @default.
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• W1577893399 date "1989-02-01" @default.
• W1577893399 modified "2023-09-27" @default.
• W1577893399 title "5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole inhibits transcription elongation by RNA polymerase II in vitro" @default.
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• W1577893399 doi "https://doi.org/10.1016/s0021-9258(18)94169-4" @default.
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• W1577893399 hasPublicationYear "1989" @default.
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