Matches in SemOpenAlex for { <https://semopenalex.org/work/W1578034565> ?p ?o ?g. }
- W1578034565 endingPage "736" @default.
- W1578034565 startingPage "723" @default.
- W1578034565 abstract "This manuscript provides a comprehensive review of the epidemiologic evidence linking type 2 diabetes (T2D) and its precursor conditions, elevated adiposity and hyperinsulinemia, to dementia. The mechanisms relating these conditions to dementia may be vascular and non-vascular. Elevated adiposity in middle age is related to a higher risk of dementia but the data on this association in old age is conflicting. Several studies have shown that hyperinsulinemia, a consequence of higher adiposity and insulin resistance, is also related to a higher risk of dementia, including late onset Alzheimer's disease (LOAD). Studies have consistently shown a relation of T2D with higher dementia risk, but the associations are stronger for vascular dementia compared to LOAD. A large proportion of the world population may be at increased risk of dementia given the trends for increasing prevalence of overweight, obesity, hyperinsulinemia, and T2D. However, these associations may present a unique opportunity for prevention and treatment of dementia. There are several known modalities that are effective in the prevention and T2D and the reduction of hyperinsulinemia including lifestyle interventions, metformin, thiazolideniodones, and acarbose. Several studies in the prevention and treatment of T2D are currently measuring cognitive outcomes and will provide information on whether T2D treatment and prevention can prevent cognitive decline and dementia." @default.
- W1578034565 created "2016-06-24" @default.
- W1578034565 creator A5029303778 @default.
- W1578034565 date "2010-05-26" @default.
- W1578034565 modified "2023-10-18" @default.
- W1578034565 title "Type 2 Diabetes, Related Conditions, in Relation and Dementia: An Opportunity for Prevention?" @default.
- W1578034565 cites W1512245923 @default.
- W1578034565 cites W1963864282 @default.
- W1578034565 cites W1970779072 @default.
- W1578034565 cites W1972527308 @default.
- W1578034565 cites W1978769917 @default.
- W1578034565 cites W1981357357 @default.
- W1578034565 cites W1982206682 @default.
- W1578034565 cites W1984044273 @default.
- W1578034565 cites W1985828326 @default.
- W1578034565 cites W1987449176 @default.
- W1578034565 cites W1993095113 @default.
- W1578034565 cites W1993119975 @default.
- W1578034565 cites W1998088268 @default.
- W1578034565 cites W1998696106 @default.
- W1578034565 cites W2001284149 @default.
- W1578034565 cites W2003106438 @default.
- W1578034565 cites W2009869050 @default.
- W1578034565 cites W2013952491 @default.
- W1578034565 cites W2015199723 @default.
- W1578034565 cites W2017199725 @default.
- W1578034565 cites W2023899218 @default.
- W1578034565 cites W2028416698 @default.
- W1578034565 cites W2031308308 @default.
- W1578034565 cites W2033125833 @default.
- W1578034565 cites W2034664059 @default.
- W1578034565 cites W2036939737 @default.
- W1578034565 cites W2038846578 @default.
- W1578034565 cites W2039079619 @default.
- W1578034565 cites W2049230496 @default.
- W1578034565 cites W2051149630 @default.
- W1578034565 cites W2052520870 @default.
- W1578034565 cites W2053937456 @default.
- W1578034565 cites W2057042201 @default.
- W1578034565 cites W2058473463 @default.
- W1578034565 cites W2058988518 @default.
- W1578034565 cites W2059313571 @default.
- W1578034565 cites W2061233470 @default.
- W1578034565 cites W2064592215 @default.
- W1578034565 cites W2066630911 @default.
- W1578034565 cites W2067982618 @default.
- W1578034565 cites W2073796605 @default.
- W1578034565 cites W2076969420 @default.
- W1578034565 cites W2078925001 @default.
- W1578034565 cites W2079063113 @default.
- W1578034565 cites W2081276121 @default.
- W1578034565 cites W2087443596 @default.
- W1578034565 cites W2088642279 @default.
- W1578034565 cites W2090221075 @default.
- W1578034565 cites W2092509345 @default.
- W1578034565 cites W2099556509 @default.
- W1578034565 cites W2103309537 @default.
- W1578034565 cites W2104565625 @default.
- W1578034565 cites W2104855192 @default.
- W1578034565 cites W2107209365 @default.
- W1578034565 cites W2107361477 @default.
- W1578034565 cites W2107501599 @default.
- W1578034565 cites W2107538126 @default.
- W1578034565 cites W2107820540 @default.
- W1578034565 cites W2108569420 @default.
- W1578034565 cites W2108762011 @default.
- W1578034565 cites W2109876897 @default.
- W1578034565 cites W2112256576 @default.
- W1578034565 cites W2113338980 @default.
- W1578034565 cites W2114456718 @default.
- W1578034565 cites W2115309909 @default.
- W1578034565 cites W2123744385 @default.
- W1578034565 cites W2124681501 @default.
- W1578034565 cites W2125361330 @default.
- W1578034565 cites W2125471430 @default.
- W1578034565 cites W2126115073 @default.
- W1578034565 cites W2127125241 @default.
- W1578034565 cites W2127151873 @default.
- W1578034565 cites W2128828378 @default.
- W1578034565 cites W2131430447 @default.
- W1578034565 cites W2146405340 @default.
- W1578034565 cites W2147363246 @default.
- W1578034565 cites W2153415741 @default.
- W1578034565 cites W2154619825 @default.
- W1578034565 cites W2156988995 @default.
- W1578034565 cites W2158822657 @default.
- W1578034565 cites W2159122349 @default.
- W1578034565 cites W2162495692 @default.
- W1578034565 cites W2162934281 @default.
- W1578034565 cites W2163625218 @default.
- W1578034565 cites W2164493941 @default.
- W1578034565 cites W2166487029 @default.
- W1578034565 cites W2166766346 @default.
- W1578034565 cites W2166853536 @default.
- W1578034565 cites W2168536185 @default.
- W1578034565 cites W2170378756 @default.
- W1578034565 cites W2172016333 @default.
- W1578034565 cites W2200438905 @default.