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- W1578113876 abstract "Progranulin (PGRN) is a pleiotropic protein that has gained the attention of the neuroscience community with recent discoveries of mutations in the gene for PGRN that cause frontotemporal lobar degeneration (FTLD). Pathogenic mutations in PGRN result in null alleles, and the disease is likely the result of haploinsufficiency. Little is known about the normal function of PGRN in the central nervous system apart from a role in brain development. It is expressed by microglia and neurons. In the periphery, PGRN is involved in wound repair and inflammation. High PGRN expression has been associated with more aggressive growth of various tumors. The properties of full length PGRN are distinct from those of proteolytically derived peptides, referred to as granulins (GRNs). While PGRN has trophic properties, GRNs are more akin to inflammatory mediators such as cytokines. Loss of the neurotrophic properties of PGRN may play a role in selective neuronal degeneration in FTLD, but neuroinflammation may also be important. Gene expression studies suggest that PGRN is up-regulated in a variety of neuroinflammatory conditions, and increased PGRN expression by microglia may play a pivotal role in the response to brain injury, neuroinflammation and neurodegeneration." @default.
- W1578113876 created "2016-06-24" @default.
- W1578113876 creator A5009533777 @default.
- W1578113876 creator A5046594351 @default.
- W1578113876 creator A5053377589 @default.
- W1578113876 creator A5059579249 @default.
- W1578113876 date "2007-02-11" @default.
- W1578113876 modified "2023-09-23" @default.
- W1578113876 title "Progranulin in frontotemporal lobar degeneration and neuroinflammation" @default.
- W1578113876 cites W1488482313 @default.
- W1578113876 cites W1563590122 @default.
- W1578113876 cites W1575263086 @default.
- W1578113876 cites W181718899 @default.
- W1578113876 cites W183334981 @default.
- W1578113876 cites W1903108056 @default.
- W1578113876 cites W1914568445 @default.
- W1578113876 cites W1964506812 @default.
- W1578113876 cites W1967932847 @default.
- W1578113876 cites W1970847354 @default.
- W1578113876 cites W1973891258 @default.
- W1578113876 cites W1974391834 @default.
- W1578113876 cites W1978483334 @default.
- W1578113876 cites W1981955070 @default.
- W1578113876 cites W1982236441 @default.
- W1578113876 cites W1984145170 @default.
- W1578113876 cites W1984615732 @default.
- W1578113876 cites W1988418980 @default.
- W1578113876 cites W1996639413 @default.
- W1578113876 cites W1997196023 @default.
- W1578113876 cites W1998928544 @default.
- W1578113876 cites W2003156240 @default.
- W1578113876 cites W2003618511 @default.
- W1578113876 cites W2004395649 @default.
- W1578113876 cites W2005731595 @default.
- W1578113876 cites W2008874237 @default.
- W1578113876 cites W2020719670 @default.
- W1578113876 cites W2021812498 @default.
- W1578113876 cites W2022734611 @default.
- W1578113876 cites W2024562130 @default.
- W1578113876 cites W2027460468 @default.
- W1578113876 cites W2027704676 @default.
- W1578113876 cites W2029401699 @default.
- W1578113876 cites W2029411593 @default.
- W1578113876 cites W2030032536 @default.
- W1578113876 cites W2030063068 @default.
- W1578113876 cites W2031964319 @default.
- W1578113876 cites W2034183549 @default.
- W1578113876 cites W2035176557 @default.
- W1578113876 cites W2035228493 @default.
- W1578113876 cites W2037478102 @default.
- W1578113876 cites W2040953865 @default.
- W1578113876 cites W2041086920 @default.
- W1578113876 cites W2041922475 @default.
- W1578113876 cites W2043090904 @default.
- W1578113876 cites W2043642541 @default.
- W1578113876 cites W2044315549 @default.
- W1578113876 cites W2045962406 @default.
- W1578113876 cites W2046700952 @default.
- W1578113876 cites W2048567613 @default.
- W1578113876 cites W2050685193 @default.
- W1578113876 cites W2055091163 @default.
- W1578113876 cites W2063019912 @default.
- W1578113876 cites W2064797576 @default.
- W1578113876 cites W2067538132 @default.
- W1578113876 cites W2067962255 @default.
- W1578113876 cites W2068872768 @default.
- W1578113876 cites W2071394393 @default.
- W1578113876 cites W2076407459 @default.
- W1578113876 cites W2079596501 @default.
- W1578113876 cites W2089232314 @default.
- W1578113876 cites W2089389165 @default.
- W1578113876 cites W2089503145 @default.
- W1578113876 cites W2090804892 @default.
- W1578113876 cites W2092197187 @default.
- W1578113876 cites W2093285420 @default.
- W1578113876 cites W2095973840 @default.
- W1578113876 cites W2097417855 @default.
- W1578113876 cites W2098758088 @default.
- W1578113876 cites W2102262051 @default.
- W1578113876 cites W2105764858 @default.
- W1578113876 cites W2109759840 @default.
- W1578113876 cites W2110038883 @default.
- W1578113876 cites W2115064726 @default.
- W1578113876 cites W2115694724 @default.
- W1578113876 cites W2126882863 @default.
- W1578113876 cites W2130916990 @default.
- W1578113876 cites W2132224714 @default.
- W1578113876 cites W2132280149 @default.
- W1578113876 cites W2139267086 @default.
- W1578113876 cites W2142946360 @default.
- W1578113876 cites W2146631683 @default.
- W1578113876 cites W2147743457 @default.
- W1578113876 cites W2157952919 @default.
- W1578113876 cites W2158784790 @default.
- W1578113876 cites W2159881591 @default.
- W1578113876 cites W2168512402 @default.
- W1578113876 cites W2168929061 @default.
- W1578113876 cites W2169514240 @default.
- W1578113876 cites W2325727928 @default.
- W1578113876 cites W4210981518 @default.