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- W1578163150 abstract "In this issue of the British Journal of Pharmacology, a new article by Kozuska et al. discusses the multiple salt bridges in the intracellular domain of the 5HT3A receptor. These interactions increase the overall rigidity of the receptor, stabilize its low conducting state and affect the ligand cooperativity. The authors suggest that the allosteric effects of these regions on the receptor may be involved in a possible 'reverse' allosteric modulation of 5HT3 receptors." @default.
- W1578163150 created "2016-06-24" @default.
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- W1578163150 date "2014-03-18" @default.
- W1578163150 modified "2023-09-24" @default.
- W1578163150 title "The tail wags the dog: possible mechanism for reverse allosteric control of ligand-activated channels" @default.
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- W1578163150 doi "https://doi.org/10.1111/bph.12550" @default.
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