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• W1578164041 abstract "The intravenous injection of 1 to 2 mg of ι-carrageenan (CAR) into (C57BL/6 × C3H)F1 or BALB/c mice causes a prompt and substantial decline of splenic natural killer (NK) activity against YAC-1 lymphoma targets lasting approximately 1 week in F1 mice. During this time, NK activity can be enhanced by administration of the interferon inducer polyinosinic-polycytidilic acid. The in vivo effect of CAR requires neither an intact thymus nor unimpaired proliferative capacity of lymphomyeloid cells, according to experiments in congenitally athymic BALB/c.nu/nu mice and in preirradiated (700 rad of γ-rays) F1 hybrids. The splenic cytotoxic activity lowered in vivo by CAR can be restored in vitro by removing subpopulations of cells that adhere to glass wool or carbonyl iron particles, but not to Sephadex G-10. Thus, the lytic function of mature NK cells is reversibly inhibited in the spleens of CAR-treated animals; differentiation and maturation of NK precursors are not inhibited, as judged by the enhancing effect on NK activity of the interferon inducer. Splenocytes of CAR-treated donors suppress cytotoxic effectors of untreated mice in cell mixing experiments. Athymic and preirradiated animals given CAR are fully competent donors of suppressor cells. Suppressor function is insensitive to irradiation (2000 rad of γ-rays in vitro) and to anti Thy-1 or anti-Ia antibody plus complement. Inhibition of NK cytolysis is not restricted by the major histocompatibility complex and can also be mediated by cell-free supernatants in which suppressor cells were incubated. This model of reversible inhibition of NK activity suggests that activation of thymus-independent suppressor cells is one of the regulatory mechanisms of natural cytotoxic activity in vivo." @default.
• W1578164041 created "2016-06-24" @default.
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• W1578164041 date "1981-06-01" @default.
• W1578164041 modified "2023-09-27" @default.
• W1578164041 title "Carrageenan-induced decline of natural killer activity" @default.
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• W1578164041 doi "https://doi.org/10.1016/0008-8749(81)90366-x" @default.
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