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- W157821080 abstract "Emerging evidence supports an “oxidative stress” theory in the pathogenesis of Alzheimer’s disease (AD). Amyloid β-protein (Aβ), one of the causative agents, forms a soluble oligomeric assembly to induce neurotoxicity, which is triggered by reactive oxygen species. Recent clinical studies suggest a preventive role of antioxidants during AD progression. Because vitamin C (VC) is a widely known nutrient or food used for its potent antioxidant properties, therapy using high-dose VC given by intravenous routes as well as dietary intake has benefits in the treatment of disease. Although there are numerous epidemiologic studies on the relevance of VC supplementation to lowering the risk of AD, the mechanism of how VC affects Aβ-induced pathologies remains entirely unclear. This short review documents recent findings on AD prevention by VC, including our own, and discusses the future directions that this research might take." @default.
- W157821080 created "2016-06-24" @default.
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- W157821080 date "2015-01-01" @default.
- W157821080 modified "2023-10-17" @default.
- W157821080 title "Potential Role of Vitamin C in the Prevention of Alzheimer’s Disease" @default.
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- W157821080 doi "https://doi.org/10.1016/b978-0-12-407824-6.00061-6" @default.
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