FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1578472912> ?p ?o ?g. }

• W1578472912 endingPage "e1042648" @default.
• W1578472912 startingPage "e1042648" @default.
• W1578472912 abstract "Homozygous mutations in SLC30A10 cause familial parkinsonism associated with manganese (Mn) retention. We recently identified SLC30A10 to be a cell surface-localized Mn efflux transporter and demonstrated that parkinsonism-causing mutations block its intracellular trafficking and efflux function. In C. elegans, SLC30A10 over-expression protected against Mn-induced lethality and dopaminergic neurotoxicity, consistent with results in mammalian systems. Here, we present new data about SLC30A10 function in C. elegans. SLC30A10 expression did not protect worms against ZnSO4toxicity, suggesting that SLC30A10 does not mediate Zn export in C. elegans. Furthermore, while a blast search identified 5 potential SLC30A10 homologs in worms (cdf-1, cdf-2, ttm-1 and toc-1; sequence identity <35%), knock-down of these genes showed a tendency of increased survival after Mn exposure (although only ttm-1 was statistically significant), suggesting that the worm homologs may function differently." @default.
• W1578472912 created "2016-06-24" @default.
• W1578472912 creator A5002802326 @default.
• W1578472912 creator A5035503566 @default.
• W1578472912 creator A5072815126 @default.
• W1578472912 creator A5081869093 @default.
• W1578472912 date "2015-05-11" @default.
• W1578472912 modified "2023-10-12" @default.
• W1578472912 title "SLC30A10: A novel manganese transporter" @default.
• W1578472912 cites W1632379109 @default.
• W1578472912 cites W1816749156 @default.
• W1578472912 cites W1970526270 @default.
• W1578472912 cites W1971970412 @default.
• W1578472912 cites W1976699788 @default.
• W1578472912 cites W1998346093 @default.
• W1578472912 cites W2001298782 @default.
• W1578472912 cites W2004213036 @default.
• W1578472912 cites W2004714156 @default.
• W1578472912 cites W2004750204 @default.
• W1578472912 cites W2024122849 @default.
• W1578472912 cites W2034413100 @default.
• W1578472912 cites W2042042950 @default.
• W1578472912 cites W2047132050 @default.
• W1578472912 cites W2059869891 @default.
• W1578472912 cites W2067354437 @default.
• W1578472912 cites W2077682304 @default.
• W1578472912 cites W2078012679 @default.
• W1578472912 cites W2095908732 @default.
• W1578472912 cites W2108886647 @default.
• W1578472912 cites W2115033644 @default.
• W1578472912 cites W2124735319 @default.
• W1578472912 cites W2144720497 @default.
• W1578472912 cites W2152798478 @default.
• W1578472912 cites W2156207817 @default.
• W1578472912 cites W2163792161 @default.
• W1578472912 cites W2165246198 @default.
• W1578472912 cites W4210952882 @default.
• W1578472912 cites W77541376 @default.
• W1578472912 doi "https://doi.org/10.1080/21624054.2015.1042648" @default.
• W1578472912 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4588552" @default.
• W1578472912 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26430566" @default.
• W1578472912 hasPublicationYear "2015" @default.
• W1578472912 type Work @default.
• W1578472912 sameAs 1578472912 @default.
• W1578472912 citedByCount "42" @default.
• W1578472912 countsByYear W15784729122016 @default.
• W1578472912 countsByYear W15784729122017 @default.
• W1578472912 countsByYear W15784729122018 @default.
• W1578472912 countsByYear W15784729122019 @default.
• W1578472912 countsByYear W15784729122020 @default.
• W1578472912 countsByYear W15784729122021 @default.
• W1578472912 countsByYear W15784729122022 @default.
• W1578472912 countsByYear W15784729122023 @default.
• W1578472912 crossrefType "journal-article" @default.
• W1578472912 hasAuthorship W1578472912A5002802326 @default.
• W1578472912 hasAuthorship W1578472912A5035503566 @default.
• W1578472912 hasAuthorship W1578472912A5072815126 @default.
• W1578472912 hasAuthorship W1578472912A5081869093 @default.
• W1578472912 hasBestOaLocation W15784729121 @default.
• W1578472912 hasConcept C104317684 @default.
• W1578472912 hasConcept C14036430 @default.
• W1578472912 hasConcept C149011108 @default.
• W1578472912 hasConcept C178790620 @default.
• W1578472912 hasConcept C185592680 @default.
• W1578472912 hasConcept C200082930 @default.
• W1578472912 hasConcept C2778944004 @default.
• W1578472912 hasConcept C528890316 @default.
• W1578472912 hasConcept C54355233 @default.
• W1578472912 hasConcept C55493867 @default.
• W1578472912 hasConcept C86803240 @default.
• W1578472912 hasConceptScore W1578472912C104317684 @default.
• W1578472912 hasConceptScore W1578472912C14036430 @default.
• W1578472912 hasConceptScore W1578472912C149011108 @default.
• W1578472912 hasConceptScore W1578472912C178790620 @default.
• W1578472912 hasConceptScore W1578472912C185592680 @default.
• W1578472912 hasConceptScore W1578472912C200082930 @default.
• W1578472912 hasConceptScore W1578472912C2778944004 @default.
• W1578472912 hasConceptScore W1578472912C528890316 @default.
• W1578472912 hasConceptScore W1578472912C54355233 @default.
• W1578472912 hasConceptScore W1578472912C55493867 @default.
• W1578472912 hasConceptScore W1578472912C86803240 @default.
• W1578472912 hasIssue "3" @default.
• W1578472912 hasLocation W15784729121 @default.
• W1578472912 hasLocation W15784729122 @default.
• W1578472912 hasLocation W15784729123 @default.
• W1578472912 hasLocation W15784729124 @default.
• W1578472912 hasOpenAccess W1578472912 @default.
• W1578472912 hasPrimaryLocation W15784729121 @default.
• W1578472912 hasRelatedWork W1991409000 @default.
• W1578472912 hasRelatedWork W2037720119 @default.
• W1578472912 hasRelatedWork W2119829136 @default.
• W1578472912 hasRelatedWork W2344360015 @default.
• W1578472912 hasRelatedWork W2373868424 @default.
• W1578472912 hasRelatedWork W2604423474 @default.
• W1578472912 hasRelatedWork W2950449520 @default.
• W1578472912 hasRelatedWork W2953182515 @default.
• W1578472912 hasRelatedWork W2999306174 @default.
• W1578472912 hasRelatedWork W3193435541 @default.

• next