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- W157856285 startingPage "1" @default.
- W157856285 abstract "The breast attains its maximum development during pregnancy and lactation. After menopause the breast regresses in both nulliparous and parous women containing lobular structures that have been designated lobules type 1. Despite the similarity in the lobular composition of the breast at menopause, the fact that nulliparous women are at higher risk of developing breast cancer than parous women indicates that lobules type 1 in these two groups of women might be biologically different, or exhibit different susceptibility to carcinogenesis. Based on these observations it was postulated that the lobule type 1 found in the breast of nulliparous women and of parous women with breast cancer never went through the process of differentiation, retaining a high concentration of epithelial cells that are targets for carcinogens and therefore susceptible to undergo neoplastic transformation, whereas lobules type 1 structures found in the breast of early parous postmenopausal women free of mammary pathology, on the other hand, are composed of an epithelial cell population that is refractory to transformation. The degree of differentiation acquired through early pregnancy has changed the genomic signature that differentiates the lobule type 1 in the early parous women from that in the nulliparous women, making this the postulated mechanism of protection conferred by early full-term pregnancy." @default.
- W157856285 created "2016-06-24" @default.
- W157856285 creator A5046511241 @default.
- W157856285 creator A5054880138 @default.
- W157856285 date "2009-01-01" @default.
- W157856285 modified "2023-09-27" @default.
- W157856285 title "The Genomic Basis of Breast Development and Differentiation" @default.
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