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• W1578563913 abstract "We examined the effect of α 1 -adrenergic receptor (AR) subtypes on contraction, cytosolic Ca 2+ concentration ([Ca 2+ ] i ), and cytosolic pH (pH i ) of rat ventricular myocytes loaded with the Ca 2+ indicator indo 1 or the pH indicator carboxy-seminaphthorhodafluor-1. Nonselective α 1 -AR stimulation was effected with phenylephrine plus nadolol. α 1 -AR subtype stimulation was achieved with α 1 -AR and chloroethylclonidine (CEC) or with α 1 -AR and WB-4101. Cells were in bicarbonate buffer with 0.5 mM Ca 2+ and were electrically stimulated at 0.5 Hz. Results show that 1) nonselective α 1 -AR stimulation increased twitch and [Ca 2+ ] i transient amplitudes, myofilament response to Ca 2+ , and pH i ; 2) α 1 -AR plus CEC increased twitch and [Ca 2+ ] i transient amplitudes and also enhanced myofilament response to Ca 2+ via cytosolic alkalinization; 3) α 1 -AR plus WB-4101 decreased twitch and [Ca 2+ ] i transient amplitudes and also pH i ; and 4) cytosolic acidification due to α 1 -AR plus WB-4101 was abolished by protein kinase C inhibition (staurosporine pretreatment) or downregulation (prolonged exposure to phorbol esters). In summary, the net effects of α 1 -adrenergic stimulation on contraction, [Ca 2+ ] i , and pH i are due to opposing WB-4101- and CEC-sensitive α 1 -AR subtype signaling pathways." @default.
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• W1578563913 date "1998-04-01" @default.
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• W1578563913 title "Opposing effects of α₁-adrenergic receptor subtypes on Ca²⁺and pH homeostasis in rat cardiac myocytes" @default.
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• W1578563913 doi "https://doi.org/10.1152/ajpheart.1998.274.4.h1152" @default.
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