FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1578814306> ?p ?o ?g. }

• W1578814306 endingPage "23781" @default.
• W1578814306 startingPage "23772" @default.
• W1578814306 abstract "Filaggrin is an intermediate filament-associated protein which functions to aggregate keratin intermediate filaments in the stratum corneum of mammalian epidermis. It is synthesized as a large precursor protein, profilaggrin, that consists of multiple filaggrin units and is localized in keratohyalin granules. In this report, we describe the characterization of cosmid genomic clones containing the human profilaggrin gene coding for 11 complete filaggrin repeats of 324 amino acids each. At the amino- and carboxyl-terminal ends of human profilaggrin are leader and tail peptide sequences of 293 and 157 amino acids, respectively, which differ from filaggrin. The leader peptide is composed of two distinct domains: an 81-residue segment which shows significant homology to the S-100 family of EF hand-containing calcium-binding proteins, and a hydrophilic second domain of 212 residues. The gene is divided into three exons, with one intron (approximately 9.6 kilobase pairs) in the 5' noncoding region and a second one of 570 base pairs between the EF hands. The position of intron 2 is identical to that of other members of the S-100-like family. The presence of an S-100-like domain suggests that profilaggrin binds calcium and that the calcium binding domain is functionally significant in the formation of keratohyalin and/or the subsequent processing of profilaggrin to filaggrin, both of which may be calcium-dependent events." @default.
• W1578814306 created "2016-06-24" @default.
• W1578814306 creator A5003234638 @default.
• W1578814306 creator A5019124267 @default.
• W1578814306 creator A5037763549 @default.
• W1578814306 creator A5055451726 @default.
• W1578814306 creator A5075287317 @default.
• W1578814306 date "1992-11-01" @default.
• W1578814306 modified "2023-10-10" @default.
• W1578814306 title "Characterization of the human epidermal profilaggrin gene. Genomic organization and identification of an S-100-like calcium binding domain at the amino terminus." @default.
• W1578814306 cites W135343356 @default.
• W1578814306 cites W1485012056 @default.
• W1578814306 cites W1502681357 @default.
• W1578814306 cites W1508636766 @default.
• W1578814306 cites W1513902446 @default.
• W1578814306 cites W1530275886 @default.
• W1578814306 cites W1574903262 @default.
• W1578814306 cites W1584008028 @default.
• W1578814306 cites W1591652724 @default.
• W1578814306 cites W1756522554 @default.
• W1578814306 cites W1944595096 @default.
• W1578814306 cites W1967004332 @default.
• W1578814306 cites W1970593927 @default.
• W1578814306 cites W1974469880 @default.
• W1578814306 cites W1974735797 @default.
• W1578814306 cites W1976105576 @default.
• W1578814306 cites W1978547603 @default.
• W1578814306 cites W1980108423 @default.
• W1578814306 cites W1981602259 @default.
• W1578814306 cites W1982581831 @default.
• W1578814306 cites W1983842882 @default.
• W1578814306 cites W1990026167 @default.
• W1578814306 cites W1991856499 @default.
• W1578814306 cites W1997473658 @default.
• W1578814306 cites W2001062031 @default.
• W1578814306 cites W2002218686 @default.
• W1578814306 cites W2010390522 @default.
• W1578814306 cites W2011317548 @default.
• W1578814306 cites W2011824801 @default.
• W1578814306 cites W2018748897 @default.
• W1578814306 cites W2021873282 @default.
• W1578814306 cites W2034520842 @default.
• W1578814306 cites W2038085058 @default.
• W1578814306 cites W2049043712 @default.
• W1578814306 cites W2051824280 @default.
• W1578814306 cites W2057488789 @default.
• W1578814306 cites W2060333964 @default.
• W1578814306 cites W2066216248 @default.
• W1578814306 cites W2068681523 @default.
• W1578814306 cites W2072798835 @default.
• W1578814306 cites W2073638852 @default.
• W1578814306 cites W2075232957 @default.
• W1578814306 cites W2076235025 @default.
• W1578814306 cites W2078566041 @default.
• W1578814306 cites W2080434495 @default.
• W1578814306 cites W2081720324 @default.
• W1578814306 cites W2085516075 @default.
• W1578814306 cites W2092240717 @default.
• W1578814306 cites W2097998324 @default.
• W1578814306 cites W2103304027 @default.
• W1578814306 cites W2104027941 @default.
• W1578814306 cites W2119297613 @default.
• W1578814306 cites W2119725374 @default.
• W1578814306 cites W2126440278 @default.
• W1578814306 cites W2134098588 @default.
• W1578814306 cites W2138270253 @default.
• W1578814306 cites W2154128645 @default.
• W1578814306 cites W2166874352 @default.
• W1578814306 cites W2326879084 @default.
• W1578814306 cites W267017029 @default.
• W1578814306 cites W2762374987 @default.
• W1578814306 cites W320318737 @default.
• W1578814306 cites W4434835 @default.
• W1578814306 cites W981450589 @default.
• W1578814306 doi "https://doi.org/10.1016/s0021-9258(18)35905-2" @default.
• W1578814306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1429717" @default.
• W1578814306 hasPublicationYear "1992" @default.
• W1578814306 type Work @default.
• W1578814306 sameAs 1578814306 @default.
• W1578814306 citedByCount "152" @default.
• W1578814306 countsByYear W15788143062012 @default.
• W1578814306 countsByYear W15788143062013 @default.
• W1578814306 countsByYear W15788143062014 @default.
• W1578814306 countsByYear W15788143062015 @default.
• W1578814306 countsByYear W15788143062016 @default.
• W1578814306 countsByYear W15788143062017 @default.
• W1578814306 countsByYear W15788143062018 @default.
• W1578814306 countsByYear W15788143062020 @default.
• W1578814306 countsByYear W15788143062021 @default.
• W1578814306 countsByYear W15788143062022 @default.
• W1578814306 countsByYear W15788143062023 @default.
• W1578814306 crossrefType "journal-article" @default.
• W1578814306 hasAuthorship W1578814306A5003234638 @default.
• W1578814306 hasAuthorship W1578814306A5019124267 @default.
• W1578814306 hasAuthorship W1578814306A5037763549 @default.
• W1578814306 hasAuthorship W1578814306A5055451726 @default.
• W1578814306 hasAuthorship W1578814306A5075287317 @default.
• W1578814306 hasBestOaLocation W15788143061 @default.

• next