Matches in SemOpenAlex for { <https://semopenalex.org/work/W157890383> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W157890383 abstract "Cytosolic phospholipase A2 (cPLA2) a plays crucial roles in the lipid mediator-biosynthetic pathway following cell activationl. Submicromolar concentrations of Ca2+ are required for cPLA2a to exert its catalytic activity, and this enzyme preferentially hydrolyses phospholipids bearing arachidonic acid2. cPLA2a exists in most mammalian cells, and its activation is regulated by several postreceptor signal transduction events, such as Ca2+ mobilization3, phosphorylation4,5, and gene induction6. Upon Ca2+mobilizing stimulation, cPLA2a translocates rapidly to the perinuclear area7-9. cPLA2a has several functionally distinct regions: an amino-terminal Ca2+-dependent lipid-binding domain (amino acids 18-138) called the C2 domainl0, a carboxy-terminal region (amino acids 179-749) containing the catalytic domain, a putative pleckstrin homology domain 11, and two critical serine residues (Ser505 and Ser727), which undergo activation-directed phosphorylation12. We recently demonstrated that the C2 domain of cPLA2 interacts with vimentin, a major component of intermeiate filaments, in a Ca2+dependent mannerl3. In this report, we have found that another cytoskeletal protein in the cytosol of fibroblasts binds to the C2 domain of cPLA2a." @default.
- W157890383 created "2016-06-24" @default.
- W157890383 creator A5020729757 @default.
- W157890383 creator A5030120964 @default.
- W157890383 creator A5075092495 @default.
- W157890383 creator A5075637868 @default.
- W157890383 date "2002-01-01" @default.
- W157890383 modified "2023-09-27" @default.
- W157890383 title "Cytosolic Phospholipase A2a Interacts With Microtubules" @default.
- W157890383 cites W1975287199 @default.
- W157890383 cites W1982732431 @default.
- W157890383 cites W1983401747 @default.
- W157890383 cites W1993764616 @default.
- W157890383 cites W2005593816 @default.
- W157890383 cites W2014636427 @default.
- W157890383 cites W2019774786 @default.
- W157890383 cites W2028724278 @default.
- W157890383 cites W2035395599 @default.
- W157890383 cites W2039376197 @default.
- W157890383 cites W2051958752 @default.
- W157890383 cites W2086955190 @default.
- W157890383 cites W2125215711 @default.
- W157890383 cites W2128303012 @default.
- W157890383 cites W2144880676 @default.
- W157890383 cites W2146388445 @default.
- W157890383 doi "https://doi.org/10.1007/978-1-4615-0193-0_4" @default.
- W157890383 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12664559" @default.
- W157890383 hasPublicationYear "2002" @default.
- W157890383 type Work @default.
- W157890383 sameAs 157890383 @default.
- W157890383 citedByCount "6" @default.
- W157890383 countsByYear W1578903832013 @default.
- W157890383 crossrefType "book-chapter" @default.
- W157890383 hasAuthorship W157890383A5020729757 @default.
- W157890383 hasAuthorship W157890383A5030120964 @default.
- W157890383 hasAuthorship W157890383A5075092495 @default.
- W157890383 hasAuthorship W157890383A5075637868 @default.
- W157890383 hasConcept C12927208 @default.
- W157890383 hasConcept C142669718 @default.
- W157890383 hasConcept C143840085 @default.
- W157890383 hasConcept C1491633281 @default.
- W157890383 hasConcept C181199279 @default.
- W157890383 hasConcept C185592680 @default.
- W157890383 hasConcept C20418707 @default.
- W157890383 hasConcept C2776414213 @default.
- W157890383 hasConcept C41625074 @default.
- W157890383 hasConcept C49658373 @default.
- W157890383 hasConcept C515207424 @default.
- W157890383 hasConcept C55493867 @default.
- W157890383 hasConcept C62478195 @default.
- W157890383 hasConcept C86803240 @default.
- W157890383 hasConcept C95444343 @default.
- W157890383 hasConcept C98539663 @default.
- W157890383 hasConceptScore W157890383C12927208 @default.
- W157890383 hasConceptScore W157890383C142669718 @default.
- W157890383 hasConceptScore W157890383C143840085 @default.
- W157890383 hasConceptScore W157890383C1491633281 @default.
- W157890383 hasConceptScore W157890383C181199279 @default.
- W157890383 hasConceptScore W157890383C185592680 @default.
- W157890383 hasConceptScore W157890383C20418707 @default.
- W157890383 hasConceptScore W157890383C2776414213 @default.
- W157890383 hasConceptScore W157890383C41625074 @default.
- W157890383 hasConceptScore W157890383C49658373 @default.
- W157890383 hasConceptScore W157890383C515207424 @default.
- W157890383 hasConceptScore W157890383C55493867 @default.
- W157890383 hasConceptScore W157890383C62478195 @default.
- W157890383 hasConceptScore W157890383C86803240 @default.
- W157890383 hasConceptScore W157890383C95444343 @default.
- W157890383 hasConceptScore W157890383C98539663 @default.
- W157890383 hasLocation W1578903831 @default.
- W157890383 hasLocation W1578903832 @default.
- W157890383 hasOpenAccess W157890383 @default.
- W157890383 hasPrimaryLocation W1578903831 @default.
- W157890383 hasRelatedWork W199650966 @default.
- W157890383 hasRelatedWork W1999045066 @default.
- W157890383 hasRelatedWork W2019774786 @default.
- W157890383 hasRelatedWork W2021721382 @default.
- W157890383 hasRelatedWork W2043634254 @default.
- W157890383 hasRelatedWork W2046210627 @default.
- W157890383 hasRelatedWork W2055761513 @default.
- W157890383 hasRelatedWork W2073316417 @default.
- W157890383 hasRelatedWork W2082412503 @default.
- W157890383 hasRelatedWork W2104414280 @default.
- W157890383 hasRelatedWork W2109108915 @default.
- W157890383 hasRelatedWork W2109757013 @default.
- W157890383 hasRelatedWork W2127158392 @default.
- W157890383 hasRelatedWork W2128303012 @default.
- W157890383 hasRelatedWork W2157489886 @default.
- W157890383 hasRelatedWork W2165578823 @default.
- W157890383 hasRelatedWork W2172202413 @default.
- W157890383 hasRelatedWork W2534425392 @default.
- W157890383 hasRelatedWork W3010889758 @default.
- W157890383 hasRelatedWork W60552487 @default.
- W157890383 isParatext "false" @default.
- W157890383 isRetracted "false" @default.
- W157890383 magId "157890383" @default.
- W157890383 workType "book-chapter" @default.