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• W1579100868 abstract "Obesity is linked to chronic inflammation in white adipose tissue (WAT) which is exacerbated by infiltrating macrophages (M&#x03A6)s. Grape powder extract (GPE) contains polyphenols that have the potential to prevent this inflammatory response that can otherwise lead to insulin resistance. Therefore, this research examined the extent to which GPE prevents lipopolysaccharide (LPS)-induced inflammatory response in human M&#x03A6s. Pretreatment of human M&#x03A6s with GPE prevented LPS-mediated activation of mitogen activated protein kinases (MAPK)s, nuclear factor kappa B (NF&#x03BA B), and activator protein (AP)-1, and induction of inflammatory genes. Furthermore, GPE decreased the capacity of LPS-stimulated M&#x03A6s to inflame adipocytes and cause insulin resistance. My preliminary data show that in the absence of LPS, quercetin (QUE), a polyphenol abundantly found in GPE, attenuated inflammatory gene expression, c-Jun N-terminal kinase (JNK) and c-Jun activation, and I&#x03BA B &#x03B1 degradation in human M&#x03A6s. In addition, QUE pretreatment of M&#x03A6s prevented insulin resistance in human adipocytes exposed to M&#x03A6-CM. Taken together, these data show that polyphenol-rich GPE decreases inflammation in human M&#x03A6s and M&#x03A6-mediated insulin resistance in human adipocytes. Lastly, these data suggest that QUE may be one of the polyphenols in GPE that decrease inflammation and insulin resistance in human M&#x03A6s and adipocytes." @default.
• W1579100868 created "2016-06-24" @default.
• W1579100868 creator A5044407135 @default.
• W1579100868 date "2010-01-01" @default.
• W1579100868 modified "2023-09-23" @default.
• W1579100868 title "Grape powder extract (GPE) attenuates markers of inflammation in human macrophages." @default.
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