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- W157922936 endingPage "185" @default.
- W157922936 startingPage "151" @default.
- W157922936 abstract "Driving under the influence of impairing drugs is a prevalent and preventable worldwide problem. Scientists are conducting pharmacodynamic and pharmacokinetic studies to help officials identify drugged drivers and remove them from the roadways. Current approaches for drugs of abuse other than alcohol first determine an estimate of time of use from concentrations of drugs and metabolites in bodily fluids following controlled drug administration. The degree of driving impairment is then suggested based on the time course of effects from pharmacodynamic studies. Reasonable estimates of impairment can be made based on currently available studies for cannabis, cocaine, amphetamines and opioids. Predictive models were published relating cannabinoid concentrations in plasma and whole blood with time of use following various routes of administration and doses. Results of performance tests and driving simulators after controlled cannabis dosing document impairment at various times after use and show that impairment can last up to eight hours for many tasks and 24 hours for complex divided-attention tasks. A few studies on other drugs report expected plasma or oral fluid concentrations with time after drug administration. Degree of impairment is dependant on dose, route of administration, and tolerance. Further pharmacokinetic and pharmacodynamic studies are needed to guide drug concentration interpretation, to develop predictive models for other drugs, and to guide development of science-based drugged driving legislation." @default.
- W157922936 created "2016-06-24" @default.
- W157922936 creator A5000016116 @default.
- W157922936 creator A5035959416 @default.
- W157922936 date "2009-01-01" @default.
- W157922936 modified "2023-09-23" @default.
- W157922936 title "Pharmacokinetics and pharmacodynamics of drugs abused in driving" @default.
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