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- W1579264805 abstract "This chapter introduces the methods to establish the genetically engineered S. typhimurium tester strain expressing human CYP and reductase (OR) and to describes the procedure of mutation assay with the established S. typhimurium tester strain. The hepatic CYP system consists of a number of CYPs; each form of CYP presents some substrate specificity to activate promutagens to their reactive intermediates capable of causing an inheritable alteration in the DNA of a cell—namely, a mutation. Because the catalytic properties of CYP even in the same family vary among animal species, it is necessary to use human CYP to predict the bio-activation of chemicals in humans. Another source of human CYP has been considered to be the heterologous expression system. Efforts have been made to establish genetically engineered Escherichia coli (E. coli) cells expressing human CYP because of an advantage of a high yield of CYP protein. The genetically engineered E. coli cells were used successfully for studies of drug metabolism. Therefore, we expected that the technology to express the human CYP and the OR in E. coli cells could also be applied to the Salmonella typhimurium cells used for the Ames test to examine the mutagenic activation of chemicals by human CYP." @default.
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- W1579264805 date "2002-01-01" @default.
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- W1579264805 title "Mutagenesis testing based on bacterial expression of human P450s" @default.
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- W1579264805 doi "https://doi.org/10.1016/s0076-6879(02)57688-6" @default.
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