FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1579264920> ?p ?o ?g. }

• W1579264920 endingPage "88" @default.
• W1579264920 startingPage "79" @default.
• W1579264920 abstract "DNA precursor synthesis can be blocked specifically by the drug hydroxyurea (HU) which has therefore been used for anticancer therapy. High concentrations of HU, however, affect other processes than DNA synthesis; nevertheless, most studies on the biological action of HU have been made with concentrations at least one order of magnitude higher than those needed for cell-growth inhibition. In this study we characterized the effects of low concentrations of HU (i.e. concentrations leading to 50% inhibition of cell growth in 72 h) on cell cycle kinetics and nucleotide pools in mouse S49 cells with various defined alterations in DNA precursor synthesis. The effect of 50 microM HU on deoxyribonucleoside triphosphate pools was a 2-3-fold decrease in the dATP and dGTP pools, with no change in the dCTP pool and a certain increase in the dTTP pool. Addition of deoxycytidine or thymidine led to a partial reversal of the growth inhibition and cell-cycle perturbation caused by HU, and was accompanied by an increased level of the deoxyribonucleoside triphosphates. Addition of purine deoxyribonucleoside gave no protection, indicating that salvage of these nucleosides could not supply precursors for DNA synthesis in T-lymphoma cells. We observed a higher sensitivity to HU of cells lacking purine nucleoside phosphorylase or with a ribonucleotide reductase with altered allosteric regulation. Cells lacking thymidine kinase or deoxycytidine kinase were just as sensitive as wild-type cells." @default.
• W1579264920 created "2016-06-24" @default.
• W1579264920 creator A5025005079 @default.
• W1579264920 creator A5068385362 @default.
• W1579264920 creator A5087478688 @default.
• W1579264920 creator A5060531438 @default.
• W1579264920 date "1987-01-01" @default.
• W1579264920 modified "2023-10-03" @default.
• W1579264920 title "Deoxyribonucleoside triphosphate metabolism and the mammalian cell cycle" @default.
• W1579264920 cites W1501164339 @default.
• W1579264920 cites W1501231487 @default.
• W1579264920 cites W1505281346 @default.
• W1579264920 cites W1542982726 @default.
• W1579264920 cites W1553542366 @default.
• W1579264920 cites W1588847275 @default.
• W1579264920 cites W1593362658 @default.
• W1579264920 cites W1626933449 @default.
• W1579264920 cites W190990920 @default.
• W1579264920 cites W1917498183 @default.
• W1579264920 cites W1966538841 @default.
• W1579264920 cites W1990756410 @default.
• W1579264920 cites W2006954794 @default.
• W1579264920 cites W2033366613 @default.
• W1579264920 cites W2034401615 @default.
• W1579264920 cites W2046571799 @default.
• W1579264920 cites W2055921092 @default.
• W1579264920 cites W2075507370 @default.
• W1579264920 cites W2084055173 @default.
• W1579264920 cites W2092089811 @default.
• W1579264920 cites W2115688162 @default.
• W1579264920 cites W2136887257 @default.
• W1579264920 cites W2178778111 @default.
• W1579264920 cites W2200113743 @default.
• W1579264920 cites W4211133593 @default.
• W1579264920 doi "https://doi.org/10.1016/0014-4827(87)90417-4" @default.
• W1579264920 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3096753" @default.
• W1579264920 hasPublicationYear "1987" @default.
• W1579264920 type Work @default.
• W1579264920 sameAs 1579264920 @default.
• W1579264920 citedByCount "21" @default.
• W1579264920 countsByYear W15792649202017 @default.
• W1579264920 crossrefType "journal-article" @default.
• W1579264920 hasAuthorship W1579264920A5025005079 @default.
• W1579264920 hasAuthorship W1579264920A5060531438 @default.
• W1579264920 hasAuthorship W1579264920A5068385362 @default.
• W1579264920 hasAuthorship W1579264920A5087478688 @default.
• W1579264920 hasConcept C104292427 @default.
• W1579264920 hasConcept C104317684 @default.
• W1579264920 hasConcept C1491633281 @default.
• W1579264920 hasConcept C153911025 @default.
• W1579264920 hasConcept C181199279 @default.
• W1579264920 hasConcept C194101687 @default.
• W1579264920 hasConcept C2776123222 @default.
• W1579264920 hasConcept C2776476023 @default.
• W1579264920 hasConcept C2776543447 @default.
• W1579264920 hasConcept C2776694085 @default.
• W1579264920 hasConcept C2777108182 @default.
• W1579264920 hasConcept C2777844706 @default.
• W1579264920 hasConcept C2779268695 @default.
• W1579264920 hasConcept C2780258809 @default.
• W1579264920 hasConcept C2780441211 @default.
• W1579264920 hasConcept C2780636463 @default.
• W1579264920 hasConcept C29537977 @default.
• W1579264920 hasConcept C4710235 @default.
• W1579264920 hasConcept C512185932 @default.
• W1579264920 hasConcept C54355233 @default.
• W1579264920 hasConcept C552990157 @default.
• W1579264920 hasConcept C55493867 @default.
• W1579264920 hasConcept C62112901 @default.
• W1579264920 hasConcept C64241487 @default.
• W1579264920 hasConcept C73573662 @default.
• W1579264920 hasConcept C86803240 @default.
• W1579264920 hasConceptScore W1579264920C104292427 @default.
• W1579264920 hasConceptScore W1579264920C104317684 @default.
• W1579264920 hasConceptScore W1579264920C1491633281 @default.
• W1579264920 hasConceptScore W1579264920C153911025 @default.
• W1579264920 hasConceptScore W1579264920C181199279 @default.
• W1579264920 hasConceptScore W1579264920C194101687 @default.
• W1579264920 hasConceptScore W1579264920C2776123222 @default.
• W1579264920 hasConceptScore W1579264920C2776476023 @default.
• W1579264920 hasConceptScore W1579264920C2776543447 @default.
• W1579264920 hasConceptScore W1579264920C2776694085 @default.
• W1579264920 hasConceptScore W1579264920C2777108182 @default.
• W1579264920 hasConceptScore W1579264920C2777844706 @default.
• W1579264920 hasConceptScore W1579264920C2779268695 @default.
• W1579264920 hasConceptScore W1579264920C2780258809 @default.
• W1579264920 hasConceptScore W1579264920C2780441211 @default.
• W1579264920 hasConceptScore W1579264920C2780636463 @default.
• W1579264920 hasConceptScore W1579264920C29537977 @default.
• W1579264920 hasConceptScore W1579264920C4710235 @default.
• W1579264920 hasConceptScore W1579264920C512185932 @default.
• W1579264920 hasConceptScore W1579264920C54355233 @default.
• W1579264920 hasConceptScore W1579264920C552990157 @default.
• W1579264920 hasConceptScore W1579264920C55493867 @default.
• W1579264920 hasConceptScore W1579264920C62112901 @default.
• W1579264920 hasConceptScore W1579264920C64241487 @default.
• W1579264920 hasConceptScore W1579264920C73573662 @default.
• W1579264920 hasConceptScore W1579264920C86803240 @default.

• next