Matches in SemOpenAlex for { <https://semopenalex.org/work/W1579488001> ?p ?o ?g. }
- W1579488001 endingPage "1046" @default.
- W1579488001 startingPage "1039" @default.
- W1579488001 abstract "It has been reported that the activation of multiple myeloma (MM) cells by CD40 induces proliferation, growth arrest, and apoptosis. To determine whether the biologic sequelae of CD40 activation in MM cells depends on p53 function, we identified temperature-sensitive p53 mutations in the RPMI 8226 (tsp53E285K) and the HS Sultan (tsp53Y163H) MM cell lines. These cells were then used as a model system of inducible wtp53-like function because wild-type-like p53 is induced at permissive (30°C) but not at restrictive (37°C) temperatures. Using p21-luciferase reporter assays, we confirmed that CD40 induces p53 transactivation in RPMI 8226 and HS Sultan cells cultured under permissive, but not restrictive, conditions. Furthermore, CD40 activation of these MM cells under permissive, but not restrictive, temperatures increased the expression of p53 and p21 mRNA and protein. Importantly, CD40 activation induced the proliferation of RPMI 8226 and HS Sultan cells at restrictive temperatures and growth arrest and increased subG1 phase cells at permissive temperatures. These data confirmed that CD40 activation might have distinct biologic sequelae in MM cells, depending on their p53 status." @default.
- W1579488001 created "2016-06-24" @default.
- W1579488001 creator A5002882959 @default.
- W1579488001 creator A5006765393 @default.
- W1579488001 creator A5030383311 @default.
- W1579488001 creator A5032464400 @default.
- W1579488001 creator A5037768223 @default.
- W1579488001 creator A5052048627 @default.
- W1579488001 creator A5054508632 @default.
- W1579488001 creator A5075947539 @default.
- W1579488001 creator A5081299017 @default.
- W1579488001 creator A5081617768 @default.
- W1579488001 creator A5091207345 @default.
- W1579488001 date "2000-02-01" @default.
- W1579488001 modified "2023-09-28" @default.
- W1579488001 title "CD40 activation mediates p53-dependent cell cycle regulation in human multiple myeloma cell lines" @default.
- W1579488001 cites W139500099 @default.
- W1579488001 cites W1495399084 @default.
- W1579488001 cites W1499666737 @default.
- W1579488001 cites W1520422891 @default.
- W1579488001 cites W1554072136 @default.
- W1579488001 cites W1568956696 @default.
- W1579488001 cites W1586624722 @default.
- W1579488001 cites W1842375597 @default.
- W1579488001 cites W1940616591 @default.
- W1579488001 cites W1967415901 @default.
- W1579488001 cites W1988603492 @default.
- W1579488001 cites W1988744332 @default.
- W1579488001 cites W1989692667 @default.
- W1579488001 cites W2003757684 @default.
- W1579488001 cites W2005889402 @default.
- W1579488001 cites W2015519364 @default.
- W1579488001 cites W2029249439 @default.
- W1579488001 cites W2059185804 @default.
- W1579488001 cites W2074114480 @default.
- W1579488001 cites W2080459043 @default.
- W1579488001 cites W2080824017 @default.
- W1579488001 cites W2086532812 @default.
- W1579488001 cites W2089800576 @default.
- W1579488001 cites W2094270522 @default.
- W1579488001 cites W2139585356 @default.
- W1579488001 cites W2149796866 @default.
- W1579488001 cites W2184975107 @default.
- W1579488001 cites W2243623761 @default.
- W1579488001 cites W2277123120 @default.
- W1579488001 cites W2291996831 @default.
- W1579488001 cites W2349179360 @default.
- W1579488001 cites W2408947676 @default.
- W1579488001 cites W2409761760 @default.
- W1579488001 cites W91158829 @default.
- W1579488001 doi "https://doi.org/10.1182/blood.v95.3.1039.003k02_1039_1046" @default.
- W1579488001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10648420" @default.
- W1579488001 hasPublicationYear "2000" @default.
- W1579488001 type Work @default.
- W1579488001 sameAs 1579488001 @default.
- W1579488001 citedByCount "61" @default.
- W1579488001 countsByYear W15794880012012 @default.
- W1579488001 countsByYear W15794880012013 @default.
- W1579488001 countsByYear W15794880012014 @default.
- W1579488001 countsByYear W15794880012015 @default.
- W1579488001 countsByYear W15794880012016 @default.
- W1579488001 countsByYear W15794880012017 @default.
- W1579488001 countsByYear W15794880012018 @default.
- W1579488001 countsByYear W15794880012021 @default.
- W1579488001 countsByYear W15794880012022 @default.
- W1579488001 crossrefType "journal-article" @default.
- W1579488001 hasAuthorship W1579488001A5002882959 @default.
- W1579488001 hasAuthorship W1579488001A5006765393 @default.
- W1579488001 hasAuthorship W1579488001A5030383311 @default.
- W1579488001 hasAuthorship W1579488001A5032464400 @default.
- W1579488001 hasAuthorship W1579488001A5037768223 @default.
- W1579488001 hasAuthorship W1579488001A5052048627 @default.
- W1579488001 hasAuthorship W1579488001A5054508632 @default.
- W1579488001 hasAuthorship W1579488001A5075947539 @default.
- W1579488001 hasAuthorship W1579488001A5081299017 @default.
- W1579488001 hasAuthorship W1579488001A5081617768 @default.
- W1579488001 hasAuthorship W1579488001A5091207345 @default.
- W1579488001 hasConcept C104317684 @default.
- W1579488001 hasConcept C1292079 @default.
- W1579488001 hasConcept C150194340 @default.
- W1579488001 hasConcept C15224491 @default.
- W1579488001 hasConcept C153911025 @default.
- W1579488001 hasConcept C154317977 @default.
- W1579488001 hasConcept C159047783 @default.
- W1579488001 hasConcept C185592680 @default.
- W1579488001 hasConcept C190283241 @default.
- W1579488001 hasConcept C202751555 @default.
- W1579488001 hasConcept C29537977 @default.
- W1579488001 hasConcept C39347974 @default.
- W1579488001 hasConcept C502942594 @default.
- W1579488001 hasConcept C54009773 @default.
- W1579488001 hasConcept C54355233 @default.
- W1579488001 hasConcept C55493867 @default.
- W1579488001 hasConcept C62112901 @default.
- W1579488001 hasConcept C81885089 @default.
- W1579488001 hasConcept C86803240 @default.
- W1579488001 hasConcept C95444343 @default.
- W1579488001 hasConceptScore W1579488001C104317684 @default.