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• W157966459 abstract "The earliest clinical descriptions of primary hyperparathyroidism point to a progressive, crippling, and sometimes-fatal metabolic bone disease. Later reports highlighted nephrolithiasis as a common feature of this disease, and it is apparent that more patients with primary hyperparathyroidism in fact have stone disease without prominent skeletal involvement. The introduction of automated, screening biochemical profiles that included the serum calcium concentration led to the discovery of primary hyperparathyroidism in large numbers of patients who had no clinical evidence of either metabolic bone or stone disease, so-called asymptomatic primary hyperparathyroidism. Asymptomatic patients appear to remain asymptomatic during many years of observation. In those patients with symptoms, the major clinical manifestation is nephrolithiasis. Many more patients, however, complain of a constellation of vague and nonspecific neurobehavioral symptoms that were not traditionally thought to be related to primary hyperparathyroidism. The prevalence of these symptoms is greater than in control populations, which may suggest a cause-and-effect relationship to primary hyperparathyroidism. However, most patients are not predictably improved by successful parathyroidectomy." @default.
• W157966459 created "2016-06-24" @default.
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• W157966459 date "2001-01-01" @default.
• W157966459 modified "2023-10-14" @default.
• W157966459 title "Clinical Course of Primary Hyperparathyroidism" @default.
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• W157966459 doi "https://doi.org/10.1016/b978-012098651-4/50025-0" @default.
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