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- W1579668743 abstract "The regulation of the formation of isoleucine-valine biosynthetic enzymes was examined to elucidate the mechanism of isoleucine-valine accumulation by α-aminobutyric acid-resistant ( abu-r ) mutants of Serratia marcescens . In the isoleucine-valine auxotroph, l -threonine dehydratase, acetohydroxy acid synthetase, and transaminase B were repressed when isoleucine, valine, and leucine were simultaneously added to minimal medium. These enzymes were derepressed at the limitation of any single branched-chain amino acid. Pantothenate, which stimulated growth of this auxotroph, had no effect on the enzyme levels. It became evident from these results that in S. marcescens isoleucine-valine biosynthetic enzymes are subject to multivalent repression by three branched-chain amino acids. The abu-r mutants had high enzyme levels in minimal medium, with or without three branched-chain amino acids. Therefore, in abu-r mutants, isoleucine-valine biosynthetic enzymes are genetically derepressed. This derepression was considered to be the primary cause for valine accumulation and increased isoleucine accumulation." @default.
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- W1579668743 date "1971-09-01" @default.
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- W1579668743 title "Multivalent Repression and Genetic Derepression of Isoleucine-Valine Biosynthetic Enzymes in Serratia marcescens" @default.
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- W1579668743 doi "https://doi.org/10.1128/jb.107.3.824-827.1971" @default.
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