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• W1579943847 endingPage "138" @default.
• W1579943847 startingPage "101" @default.
• W1579943847 abstract "The brain is a remarkably complex anatomical structure that contains a diverse array of subdivisions, cell types, and synaptic connections. It is equally extraordinary in its physiological properties, as it constantly evaluates and integrates external stimuli as well as controls a complicated internal environment. The brain can be divided into three primary broad regions: the forebrain, midbrain (Mb), and hindbrain (Hb), each of which contain further subdivisions. The regions considered in this chapter are the Mb and most-anterior Hb (Mb/aHb), which are derived from the mesencephalon (mes) and rhombomere 1 (r1), respectively. The dorsal Mb consists of the laminated superior colliculus and the globular inferior colliculus (Fig. 1A and B), which modulate visual and auditory stimuli, respectively. The dorsal component of the aHb is the highly foliated cerebellum (Cb), which is primarily attributed to controlling motor skills (Fig. 1A and B). In contrast, the ventral Mb/aHb (Fig. 1B) consists of distinct clusters of neurons that together comprise a network of nuclei and projections-notably, the Mb dopaminergic and Hb serotonergic and Mb/aHb cholinergic neurons (Fig. 1G and H), which modulate a collection of behaviors, including movement, arousal, feeding, wakefulness, and emotion. Historically, the dorsal Mb and Cb have been studied using the chick as a model system because of the ease of performing both cell labeling and tissue transplants in the embryo in ovo; currently DNA electroporation techniques are also used. More recently the mouse has emerged as a powerful genetic system with numerous advantages to study events underpinning Mb/aHb development. There is a diverse array of spontaneous mutants with both Mb- and Cb-related phenotypes. In addition, numerous gene functions have been enumerated in mouse, gene expression is similar across vertebrates, and powerful genetic tools have been developed. Finally, additional insight into Mb/aHb function has been gained from studies of genetic diseases, such as Parkinson's disease, schizophrenia, cancer, and Dandy Walker syndrome, that afflict the Mb/aHb in humans and have genetic counterparts in mouse. Accordingly, this chapter discusses a spectrum of experiments, including classic embryology, in vitro assays, sophisticated genetic methods, and human diseases. We begin with an overview of Mb and aHb anatomy and physiology and mes/r1 gene expression patterns. We then provide a summary of fate-mapping studies that collectively demonstrate the complex cell behaviors that occur while the Mb and aHb primordia are established during embryogenesis and discuss the integration of both anterior-posterior (A-P) and dorsal-ventral (D-V) patterning. Finally, we describe some aspects of postnatal development and some of the insights gained from human diseases." @default.
• W1579943847 created "2016-06-24" @default.
• W1579943847 creator A5041948504 @default.
• W1579943847 creator A5074022782 @default.
• W1579943847 creator A5074782079 @default.
• W1579943847 date "2005-01-01" @default.
• W1579943847 modified "2023-10-07" @default.
• W1579943847 title "Classical Embryological Studies and Modern Genetic Analysis of Midbrain and Cerebellum Development" @default.
• W1579943847 cites W1480539898 @default.
• W1579943847 cites W1487003008 @default.
• W1579943847 cites W1499845615 @default.
• W1579943847 cites W1507664203 @default.
• W1579943847 cites W1534997736 @default.
• W1579943847 cites W1540812229 @default.
• W1579943847 cites W1583039655 @default.
• W1579943847 cites W1609321187 @default.
• W1579943847 cites W1611895582 @default.
• W1579943847 cites W1618939505 @default.
• W1579943847 cites W1650647918 @default.
• W1579943847 cites W1658437261 @default.
• W1579943847 cites W1730711798 @default.
• W1579943847 cites W1768274470 @default.
• W1579943847 cites W1793342589 @default.
• W1579943847 cites W1826261498 @default.
• W1579943847 cites W1848206716 @default.
• W1579943847 cites W1853890854 @default.
• W1579943847 cites W1860779656 @default.
• W1579943847 cites W1895052039 @default.
• W1579943847 cites W1896654079 @default.
• W1579943847 cites W1907712000 @default.
• W1579943847 cites W1922106993 @default.
• W1579943847 cites W1931833239 @default.
• W1579943847 cites W1948116794 @default.
• W1579943847 cites W1954303037 @default.
• W1579943847 cites W1959046600 @default.
• W1579943847 cites W1964620825 @default.
• W1579943847 cites W1965444020 @default.
• W1579943847 cites W1968707675 @default.
• W1579943847 cites W1970669095 @default.
• W1579943847 cites W1972273654 @default.
• W1579943847 cites W1972354147 @default.
• W1579943847 cites W1972727772 @default.
• W1579943847 cites W1972798612 @default.
• W1579943847 cites W1973222053 @default.
• W1579943847 cites W1974068602 @default.
• W1579943847 cites W1976886867 @default.
• W1579943847 cites W1977025966 @default.
• W1579943847 cites W1978147601 @default.
• W1579943847 cites W1978809889 @default.
• W1579943847 cites W1978841461 @default.
• W1579943847 cites W1979414180 @default.
• W1579943847 cites W1981437331 @default.
• W1579943847 cites W1981862471 @default.
• W1579943847 cites W1982087641 @default.
• W1579943847 cites W1989194294 @default.
• W1579943847 cites W1990212128 @default.
• W1579943847 cites W1990481063 @default.
• W1579943847 cites W1991771956 @default.
• W1579943847 cites W1992865216 @default.
• W1579943847 cites W1993465232 @default.
• W1579943847 cites W1996885705 @default.
• W1579943847 cites W2001961155 @default.
• W1579943847 cites W2002912842 @default.
• W1579943847 cites W2003426511 @default.
• W1579943847 cites W2003604127 @default.
• W1579943847 cites W2004201400 @default.
• W1579943847 cites W2004275727 @default.
• W1579943847 cites W2004872916 @default.
• W1579943847 cites W2006136865 @default.
• W1579943847 cites W2010132676 @default.
• W1579943847 cites W2010261844 @default.
• W1579943847 cites W2012199249 @default.
• W1579943847 cites W2012736778 @default.
• W1579943847 cites W2014468794 @default.
• W1579943847 cites W2015061512 @default.
• W1579943847 cites W2016085626 @default.
• W1579943847 cites W2018686727 @default.
• W1579943847 cites W2018834244 @default.
• W1579943847 cites W2029967811 @default.
• W1579943847 cites W2033291406 @default.
• W1579943847 cites W2034564714 @default.
• W1579943847 cites W2035502959 @default.
• W1579943847 cites W2037656814 @default.
• W1579943847 cites W2037801512 @default.
• W1579943847 cites W2038742877 @default.
• W1579943847 cites W2040785510 @default.
• W1579943847 cites W2053062490 @default.
• W1579943847 cites W2054244592 @default.
• W1579943847 cites W2059241101 @default.
• W1579943847 cites W2059362512 @default.
• W1579943847 cites W2059614045 @default.
• W1579943847 cites W2061072376 @default.
• W1579943847 cites W2062277719 @default.
• W1579943847 cites W2062928655 @default.
• W1579943847 cites W2063852715 @default.
• W1579943847 cites W2066433054 @default.
• W1579943847 cites W2066598484 @default.
• W1579943847 cites W2067263369 @default.

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