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- W1579992507 abstract "Morc1 gene has recently been identified by a DNA methylation and genome-wide association study as a candidate gene for major depressive disorder related to early life stress in rodents, primates and humans. So far, no transgenic animal model has been established to validate these findings on a behavioral level. In the present study, we examined the effects of a Morc1 loss of function mutation in female C57BL/6N mice on behavioral correlates of mood disorders like the Forced Swim Test, the Learned Helplessness Paradigm, O-Maze and Dark-Light-Box. We could show that Morc1−/− mice display increased depressive-like behavior whereas no behavioral abnormalities regarding locomotor activity or anxiety-like behavior were detectable. CORT plasma levels did not differ significantly between Morc1−/− mice and their wildtype littermates, yet – surprisingly – total Bdnf mRNA-levels in the hippocampus were up-regulated in Morc1−/− animals. Although further work would be clarifying, Morc1−/− mice seem to be a promising epigenetically validated mouse model for depression associated with early life stress." @default.
- W1579992507 created "2016-06-24" @default.
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- W1579992507 date "2016-01-01" @default.
- W1579992507 modified "2023-10-03" @default.
- W1579992507 title "Morc1 knockout evokes a depression-like phenotype in mice" @default.
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- W1579992507 doi "https://doi.org/10.1016/j.bbr.2015.08.005" @default.
- W1579992507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26275923" @default.
- W1579992507 hasPublicationYear "2016" @default.
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