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- W1580034589 abstract "Tuberculosi s dru g resistanc e i s increasin g especiall y i n multidrug-resistan t tuberculosis (MDR TB) and extensively drug resistant tuberculosis (XDR TB). Drugs susceptibility testing (DST) not only first line drugs (FLD) but also second line drugs (SLD) are useful for effective treatment and prevention the spread of tuberculosis. We evaluated susceptibility testing to second line drugs in The Office of Disease Prevention and Control 7th (DPC7) Thailand and determined the prevalence of MDR and XDR TB during 2008-2010 in Ubonratchatani province. This study composed of 3 parts. First, we determuned the prevalence of MDR and XDR TB in North-eastern area. The results revealed that the prevalence of TB in patients with HIV infection, MDR TB and XDR TB were 8.3%, 3.3% and 1.7% respectively. The patterns of monodrug resistance on first line drug as isoniazid, rifampicin ethambutol and streptomycin were 14.2%, 3.8%, 2.4% and 6.4% respectively and the resistant rate to the second line drug as kanamycin, ofloxacin, para-aminosalicyli c aci d an d ethionamid e wer e 3.4% , 15.3% , 10.2 % an d 13.6 % respectively . Second , w e compare d ou r MGIT96 0 secon d lin e DS T wit h th e result s b y L J medi a fro m Supr a Nationa l T B Referenc e Laborator y (SRL , a s gol d standard) . Th e result s reveale d that the concordance of kanamycin, ofloxacin, para-aminosalicylic acid and ethionamide were 96.4%, 96.4%, 83.1%, and 62.7% respectively. Finally, we analyzed the turn around time and unit cost of the susceptibility testing. The results revealed that the unit cost of MGIT and LJ medium second line drug susceptibility testing were 1,460.8 baht and 791.6 baht respectively. The turn around time of MGIT and LJ medium were 10 days and 40 days after the organism were isolated from specimens. In conclusion, drug resistance TB is a very importance problem in Ubonratchatani, Thailand. The SLD testing by MGIT 960 is a reliable and rapid method for facing this problem." @default.
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- W1580034589 date "2011-08-01" @default.
- W1580034589 modified "2023-09-23" @default.
- W1580034589 title "Drug resistance patterns and evaluation of susceptibility testing of multidrug resistant Mycobacterium tuberculosis to second line drug by liquid media in Ubonratchatani Thailand" @default.
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