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- W1580075467 abstract "INTRODUCTION For the maxilla, in case of a post-traumatic loss or of a major post-edentation resorption, functional and esthetic rehabilitation with a fixed prosthesis can be achieved by means of two or four zygomatic fixtures plus two to four conventional implants in the anterior region. In these cases, a reconstruction of the anterior part of the maxilla can be performed, using a bone autograft completed with an allograft and autologous platelet concentrates PlateletRich Plasma (PRP) which have been shown to enhance the maturation rate of bone, bone density, as well as to accelerate resorption of some biomaterials particules. The large number of platelets they contain release significant quantities of growth factors ( PDGF-aa, PDGF-ab, PDGF-bb, TGF-β1, TGFβ2, VEGF, EGF), which promote neovascularization and osseous regeneration, by the way of mitogenic and chimiotactic effects on mesenchymal Stem Cells, pre-osteoblastic and osteoblastic cells . The cell adhesion molecules they contain (fibrine, fibronectin, vitronectin) act as a matrix for bone regeneration and play a role in osteoconduction. Platelet concentrates are used in the form of gel and/or membranes, and are easy to apply in clinical practice. They offer potential benefits including rapid wound healing and bone regeneration, enhanced bone graft density and maturation, and accelerated resorption of biomaterial particules. METHODS AND MATERIALS A clinical case is presented, involving placement of two zygomatic fixtures, in conjunction with a cranial autograft, completed by use of particulated Freeze Dried Bone Allograft (FDBA) and Platelet-Rich Plasma (PRP) in the form of gel and membranes. Biopsies were taken 5 months after bone grafting, at the time of implant placement in the region of the anterior maxilla. Histological analysis was performed, in order to evaluate the effects of PRP on bone maturation and bone density, in the case of the use of a bone autograft in conjunction with an allograft ." @default.
- W1580075467 created "2016-06-24" @default.
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- W1580075467 date "2011-11-03" @default.
- W1580075467 modified "2023-09-28" @default.
- W1580075467 title "P2 - A COMBINATION OF ZYGOMATIC FIXTURES , AUTOGRAFT, ALLOGRAFT AND PRP (PLATELET-RICH-PLASMA ) ALLOWS A FIXED PROSTHETIC REHABILITATION OF THE MAXILLA, IN CASE OF SEVERE POST-TRAUMATIC BONE LOSS" @default.
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