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• W1580092175 abstract "<b><i>Background/Aims:</i></b> The C1431T polymorphism of peroxisome proliferator activated receptor-&#947; (PPAR-&#947;) gene is related to diabetes and metabolic-syndrome. However, studies have been inconclusive about its association with coronary artery disease (CAD) and there have been no studies analyzing the association of this polymorphism with fasted-serum-lipid levels in Iranian-individuals with CAD. We investigated the association of PPAR-&#947; C1431T-polymorphism with CAD and dyslipidaemia in 787 individuals. <b><i>Methods:</i></b> Anthropometric-parameters and biochemical-measurements were evaluated, followed by genotyping. The association of the genetic-polymorphisms with CAD and lipid-profile was determined by univariate/multivariate-analyses. <b><i>Results:</i></b> Patients with CT or CT+TT genotype were at an increased-risk of CAD relative to CC-carriers (adjusted odds ratio: 2.03; 95% con&#xFB01;dence interval, 1.01-4.09; p = 0.046). However, in the larger population, CT genotype was present at a higher frequency in the group with a positive angiogram. Furthermore, CT+TT genotypes were associated with an altered fasted-lipid-profile in the initial population sample of patients with a positive angiogram, compared to the group with a negative-angiogram. The angiogram-positive patients carrying the T allele had a significantly higher triglyceride, serum C-reactive protein and fasting-blood-glucose. <b><i>Conclusion:</i></b> We have found the PPAR-&#947; C1431T polymorphism was significantly associated with fasted serum lipid profile in individuals with angiographically defined CAD. Since accumulating data support the role of PPAR-&#947; polymorphisms in CAD, further studies are required to investigate the association of this polymorphism with coronary artery disease." @default.
• W1580092175 created "2016-06-24" @default.
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• W1580092175 date "2015-01-01" @default.
• W1580092175 modified "2023-10-18" @default.
• W1580092175 title "Impact of the C1431T Polymorphism of the Peroxisome Proliferator Activated Receptor-Gamma (PPAR-&#947;) Gene on Fasted Serum Lipid Levels in Patients with Coronary Artery Disease" @default.
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• W1580092175 doi "https://doi.org/10.1159/000381358" @default.
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