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- W1580122556 abstract "Proc Amer Assoc Cancer Res, Volume 47, 20064660 Ginseng root extract inhibits the proliferation of human cancer cells in vitro, including those that represent many common cancers. Doxorubicin (or Adriamycin) is a chemotherapy drug used in the treatment of a number of cancers, including breast cancer. As breast cancer patients may take ginseng supplements, this study was designed to examine potential interactions between water-extracted ginseng (GE) and doxorubicin (DOX) on human breast cancer MCF-7 and MDA-MB-231 cell proliferation in vitro and tumor growth in vivo, and to determine the mechanism(s) of GE action on cancer cells. First, cells were treated with a wide concentration-range of GE (0-2mg/ml) or DOX (0-50ng/ml) and cell number was mea sured after 6 days. The IC50 concentrations for GE were 0.5 and 0.6mg/ml and for DOX were 5.6 and 1.5ng/ml in MCF and MDA cells, respectively. When cells were co-treated with DOX and the IC50 concentration of GE, a synergistic interaction occurred with MCF (IC50= 0.23ng/ml) and MDA cells (0.07ng/ml), respectively. Next, female nude mice were inoculated with MCF cells and provided ad libitum treatment with GE (1% in lieu of drinking water) or DOX (1.75mg/kg, ip, 5X/week), alone or in combination. Treatment with GE or DOX significantly decreased tumor size (p 2.5-fold) expression of pRb and pErk1/2 compared to controls. In DOX+GE cells or tumor tissue, there was a significant increase in p21 and decrease in pRb relative to DOX alone. Together, these data indicate that DOX+GE is more efficacious than either DOX or GE alone in the inhibition of human breast cancer cell proliferation in vitro and tumor growth in vivo. Moreover, the synergistic interactions between DOX and GE appear to be mediated, in part, by changes in pRb. (Funded by NCCAM grant no. AT001544)" @default.
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- W1580122556 date "2006-04-15" @default.
- W1580122556 modified "2023-09-23" @default.
- W1580122556 title "Ginseng augments doxorubicin-induced inhibition of human breast cancer cell proliferation and tumor growth: mechanisms of action" @default.
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