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• W1580147641 abstract "Reliable detection of cis-regulatory elements in promoter regions is a difficult and unsolved problem in computational biology. The intricacy of transcriptional regulation in higher eukaryotes, primarily in metazoans, could be a major driving force of organismal complexity. Eukaryotic genome annotations have improved greatly due to large-scale characterization of full-length cDNAs, transcriptional start sites (TSSs), and comparative genomics. Regulatory elements are identified in promoter regions using a variety of enumerative or alignment-based methods. Here we present a survey of recent computational methods for eukaryotic promoter analysis and describe the use of an alignment-based method implemented in the A-GLAM program." @default.
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• W1580147641 date "2009-01-01" @default.
• W1580147641 modified "2023-10-16" @default.
• W1580147641 title "Promoter Analysis: Gene Regulatory Motif Identification with A-GLAM" @default.
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• W1580147641 doi "https://doi.org/10.1007/978-1-59745-251-9_13" @default.
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