Matches in SemOpenAlex for { <https://semopenalex.org/work/W158014797> ?p ?o ?g. }
- W158014797 endingPage "CMT.S2042" @default.
- W158014797 startingPage "CMT.S2042" @default.
- W158014797 abstract "Bevacizumab is a humanised monoclonal antibody targeted to the vascular endothelial growth factor (VEGF). VEGF is the ligand for VEGF receptors (VEGFR), which are important for the development and maintenance of the angiogenic phenotype in high-grade solid tumors, including malignant gliomas. An overview of angiogenesis, VEGF, VEGFR, and the pharmacology of bevacizumab will be presented. Bevacizumab is active in pre-clinical testing against glioma tissue cultures and xenograft models. In the clinical setting, in combination with irinotecan and other chemotherapy agents, it has shown significant activity in patients with glioblastoma multiforme (GBM) and other brain tumors. Objective responses on neuro-imaging have been noted in 30%-60% of reported cases. Prolongation of progression-free survival and overall survival have also been suggested in many reports. Treatment of bevacizumab is associated with potential side effects, including thromboembolic disorders, fatigue, intracranial hemorrhage, proteinuria, hypertension, and bowel perforation." @default.
- W158014797 created "2016-06-24" @default.
- W158014797 creator A5068943487 @default.
- W158014797 date "2009-01-01" @default.
- W158014797 modified "2023-09-27" @default.
- W158014797 title "Bevacizumab: Review of Development, Pharmacology, and Application to Brain Tumors" @default.
- W158014797 cites W1232974837 @default.
- W158014797 cites W1499520412 @default.
- W158014797 cites W1537712767 @default.
- W158014797 cites W1550975546 @default.
- W158014797 cites W1567768016 @default.
- W158014797 cites W1583926224 @default.
- W158014797 cites W1603230122 @default.
- W158014797 cites W1969328947 @default.
- W158014797 cites W1969656908 @default.
- W158014797 cites W1976748435 @default.
- W158014797 cites W1981289962 @default.
- W158014797 cites W1983797430 @default.
- W158014797 cites W1984020427 @default.
- W158014797 cites W1997971145 @default.
- W158014797 cites W2001060576 @default.
- W158014797 cites W2002049222 @default.
- W158014797 cites W2002424169 @default.
- W158014797 cites W2002727873 @default.
- W158014797 cites W2013897414 @default.
- W158014797 cites W2018016372 @default.
- W158014797 cites W2019746097 @default.
- W158014797 cites W2020021293 @default.
- W158014797 cites W2021491432 @default.
- W158014797 cites W2022008510 @default.
- W158014797 cites W2024946751 @default.
- W158014797 cites W2026284057 @default.
- W158014797 cites W2027016618 @default.
- W158014797 cites W2028516762 @default.
- W158014797 cites W2030964553 @default.
- W158014797 cites W2031499319 @default.
- W158014797 cites W2033288321 @default.
- W158014797 cites W2038101220 @default.
- W158014797 cites W2040116142 @default.
- W158014797 cites W2043126243 @default.
- W158014797 cites W2049827480 @default.
- W158014797 cites W2052066839 @default.
- W158014797 cites W2052824223 @default.
- W158014797 cites W2053375897 @default.
- W158014797 cites W2062594120 @default.
- W158014797 cites W2064325114 @default.
- W158014797 cites W2064735785 @default.
- W158014797 cites W2067055586 @default.
- W158014797 cites W2068427129 @default.
- W158014797 cites W2068505716 @default.
- W158014797 cites W2069826874 @default.
- W158014797 cites W2071684114 @default.
- W158014797 cites W2071752743 @default.
- W158014797 cites W2074823829 @default.
- W158014797 cites W2076424556 @default.
- W158014797 cites W2077603264 @default.
- W158014797 cites W2079096896 @default.
- W158014797 cites W2079150475 @default.
- W158014797 cites W2083479959 @default.
- W158014797 cites W2083900067 @default.
- W158014797 cites W2085724817 @default.
- W158014797 cites W2087990401 @default.
- W158014797 cites W2088925558 @default.
- W158014797 cites W2093062161 @default.
- W158014797 cites W2093084676 @default.
- W158014797 cites W2093334927 @default.
- W158014797 cites W2093783077 @default.
- W158014797 cites W2099059965 @default.
- W158014797 cites W2099279915 @default.
- W158014797 cites W2104938382 @default.
- W158014797 cites W2105121109 @default.
- W158014797 cites W2105431194 @default.
- W158014797 cites W2109606826 @default.
- W158014797 cites W2111229057 @default.
- W158014797 cites W2121785313 @default.
- W158014797 cites W2122724278 @default.
- W158014797 cites W2123748842 @default.
- W158014797 cites W2127745545 @default.
- W158014797 cites W2129331774 @default.
- W158014797 cites W2130139391 @default.
- W158014797 cites W2132482143 @default.
- W158014797 cites W2132697290 @default.
- W158014797 cites W2139008103 @default.
- W158014797 cites W2143359866 @default.
- W158014797 cites W2145058731 @default.
- W158014797 cites W2145224595 @default.
- W158014797 cites W2153586130 @default.
- W158014797 cites W2160382843 @default.
- W158014797 cites W2162822594 @default.
- W158014797 cites W2162872529 @default.
- W158014797 cites W2164626835 @default.
- W158014797 cites W2166573361 @default.
- W158014797 cites W2166708153 @default.
- W158014797 cites W2166900524 @default.
- W158014797 cites W2166921825 @default.
- W158014797 cites W2170249858 @default.
- W158014797 cites W2170367762 @default.
- W158014797 cites W2171441333 @default.