Matches in SemOpenAlex for { <https://semopenalex.org/work/W1580162959> ?p ?o ?g. }
Showing items 1 to 58 of
58
with 100 items per page.
- W1580162959 abstract "Corticotropin releasing factor (CRF) and urocortins (UCNs) are important ligands in the CRF signaling pathways, most well-known from the hypothalamic-pituitary-adrenal stress axis. However, peripheral CRF signaling has profound effects on gastrointestinal functions. Despite the potential of the murine animal model in elucidating this complexly balanced pathway through genetic manipulation, little is known regarding the expression of CRF and UCNs in the intestinal wall of the mouse. This study therefore investigates the cellular localization of CRF and UCNs in the ileum and examines how this cellular expression is altered in intestinal schistosomiasis. The results show a diverse expression of CRF and UCNs in the enteric nervous system, granulocytes and the ileal musculature. Of special interest was the de novo expression of UCN3 in a majority of submucous vasodilator/secretomotor neurons, possibly strengthening CRF2-mediated effects during inflammation. In conclusion, we outline for the first time the ileal expression of CRF signaling ligands in the mouse, and point to important changes of this signaling system in intestinal inflammation. Grant Funding Source: Supported by a grant of the Flemish Organization for Scientific Research (FWO G.0179.08)" @default.
- W1580162959 created "2016-06-24" @default.
- W1580162959 creator A5000207645 @default.
- W1580162959 creator A5013021097 @default.
- W1580162959 creator A5026171598 @default.
- W1580162959 creator A5032389760 @default.
- W1580162959 creator A5043500725 @default.
- W1580162959 creator A5048877164 @default.
- W1580162959 date "2014-04-01" @default.
- W1580162959 modified "2023-10-16" @default.
- W1580162959 title "Differential expression of corticotropin releasing factor and urocortins in the Schistosoma mansoni ‐infected mouse ileum (214.2)" @default.
- W1580162959 doi "https://doi.org/10.1096/fasebj.28.1_supplement.214.2" @default.
- W1580162959 hasPublicationYear "2014" @default.
- W1580162959 type Work @default.
- W1580162959 sameAs 1580162959 @default.
- W1580162959 citedByCount "0" @default.
- W1580162959 crossrefType "journal-article" @default.
- W1580162959 hasAuthorship W1580162959A5000207645 @default.
- W1580162959 hasAuthorship W1580162959A5013021097 @default.
- W1580162959 hasAuthorship W1580162959A5026171598 @default.
- W1580162959 hasAuthorship W1580162959A5032389760 @default.
- W1580162959 hasAuthorship W1580162959A5043500725 @default.
- W1580162959 hasAuthorship W1580162959A5048877164 @default.
- W1580162959 hasConcept C134018914 @default.
- W1580162959 hasConcept C169760540 @default.
- W1580162959 hasConcept C203014093 @default.
- W1580162959 hasConcept C2776914184 @default.
- W1580162959 hasConcept C2777226302 @default.
- W1580162959 hasConcept C62478195 @default.
- W1580162959 hasConcept C86803240 @default.
- W1580162959 hasConcept C95444343 @default.
- W1580162959 hasConceptScore W1580162959C134018914 @default.
- W1580162959 hasConceptScore W1580162959C169760540 @default.
- W1580162959 hasConceptScore W1580162959C203014093 @default.
- W1580162959 hasConceptScore W1580162959C2776914184 @default.
- W1580162959 hasConceptScore W1580162959C2777226302 @default.
- W1580162959 hasConceptScore W1580162959C62478195 @default.
- W1580162959 hasConceptScore W1580162959C86803240 @default.
- W1580162959 hasConceptScore W1580162959C95444343 @default.
- W1580162959 hasIssue "S1" @default.
- W1580162959 hasLocation W15801629591 @default.
- W1580162959 hasOpenAccess W1580162959 @default.
- W1580162959 hasPrimaryLocation W15801629591 @default.
- W1580162959 hasRelatedWork W1571778651 @default.
- W1580162959 hasRelatedWork W1827305558 @default.
- W1580162959 hasRelatedWork W1965189255 @default.
- W1580162959 hasRelatedWork W2316013418 @default.
- W1580162959 hasRelatedWork W2320606495 @default.
- W1580162959 hasRelatedWork W2375538810 @default.
- W1580162959 hasRelatedWork W2562364476 @default.
- W1580162959 hasRelatedWork W2903223704 @default.
- W1580162959 hasRelatedWork W2945783588 @default.
- W1580162959 hasRelatedWork W4212844121 @default.
- W1580162959 hasVolume "28" @default.
- W1580162959 isParatext "false" @default.
- W1580162959 isRetracted "false" @default.
- W1580162959 magId "1580162959" @default.
- W1580162959 workType "article" @default.