Matches in SemOpenAlex for { <https://semopenalex.org/work/W1580265037> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W1580265037 endingPage "3536" @default.
- W1580265037 startingPage "3530" @default.
- W1580265037 abstract "Abstract Cytotoxic T lymphocytes, generated in C57BL/6 mice in response to herpes simplex virus type 1 (HSV) and known to be restricted in their recognition of HSV-encoded antigen(s) in association with the class I H-2Kb gene product, were consistently found to contain a subpopulation that recognized and lysed uninfected, SV40-transformed cells that expressed the H-2Kbm3 and H-2Kbm11 mutant class I gene products on their cell surface. The mutant cell lines, designated Lgbm3SV and Kbm11SV, share a common amino acid substitution at position 77, with the bm3 mutation having an additional amino acid substitution at position 89. Cross-reactive lysis was observed only after in vivo priming with HSV, suggesting an important role for an antigen-dependent driving step in the expansion of these cross-reactive CTL. The phenotype of the cross-reactive effector population was further confirmed as a T lymphocyte by negative-selection techniques. Limiting dilution analysis of the frequency of cross-reactive CTL precursors suggested that cross-reactivity was mediated by a subpopulation of HSV-specific CTL, and this was confirmed by clonal analysis of the reactivity patterns of short-term, HSV-specific CTL clones. However, analysis of the specificity of the cross-reactive CTL population by cold-target inhibition of bulk culture-derived CTL, or by Spearman ranking analysis of limiting dilution-derived CTL, indicated that the specificity of the cross-reactive population for HSV-infected H-2b target cells and for uninfected bm3 or bm11 target cells was quite distinct. These findings suggested that the cross-reactive CTL population played little, if any, role in the HSV-specific CTL response as measured in vitro. The findings also suggested that the HSV-specific CTL clones able to mediate cross-reactive recognition of the bm3 and bm11 targets had a higher intrinsic avidity for the foreign target than for the inducing antigen." @default.
- W1580265037 created "2016-06-24" @default.
- W1580265037 creator A5067145311 @default.
- W1580265037 date "1985-11-01" @default.
- W1580265037 modified "2023-09-24" @default.
- W1580265037 title "Cross-reactive recognition of mouse cells expressing the bm3 and bm11 mutations within H-2Kb by H-2Kb-restricted herpes simplex virus-specific cytotoxic T lymphocytes." @default.
- W1580265037 doi "https://doi.org/10.4049/jimmunol.135.5.3530" @default.
- W1580265037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2413124" @default.
- W1580265037 hasPublicationYear "1985" @default.
- W1580265037 type Work @default.
- W1580265037 sameAs 1580265037 @default.
- W1580265037 citedByCount "8" @default.
- W1580265037 crossrefType "journal-article" @default.
- W1580265037 hasAuthorship W1580265037A5067145311 @default.
- W1580265037 hasBestOaLocation W15802650371 @default.
- W1580265037 hasConcept C100701293 @default.
- W1580265037 hasConcept C104317684 @default.
- W1580265037 hasConcept C143065580 @default.
- W1580265037 hasConcept C147483822 @default.
- W1580265037 hasConcept C147969180 @default.
- W1580265037 hasConcept C153911025 @default.
- W1580265037 hasConcept C154317977 @default.
- W1580265037 hasConcept C159047783 @default.
- W1580265037 hasConcept C202751555 @default.
- W1580265037 hasConcept C203014093 @default.
- W1580265037 hasConcept C2522874641 @default.
- W1580265037 hasConcept C2781196997 @default.
- W1580265037 hasConcept C2908647359 @default.
- W1580265037 hasConcept C2992881475 @default.
- W1580265037 hasConcept C55493867 @default.
- W1580265037 hasConcept C59822182 @default.
- W1580265037 hasConcept C71924100 @default.
- W1580265037 hasConcept C81444415 @default.
- W1580265037 hasConcept C86803240 @default.
- W1580265037 hasConcept C99454951 @default.
- W1580265037 hasConceptScore W1580265037C100701293 @default.
- W1580265037 hasConceptScore W1580265037C104317684 @default.
- W1580265037 hasConceptScore W1580265037C143065580 @default.
- W1580265037 hasConceptScore W1580265037C147483822 @default.
- W1580265037 hasConceptScore W1580265037C147969180 @default.
- W1580265037 hasConceptScore W1580265037C153911025 @default.
- W1580265037 hasConceptScore W1580265037C154317977 @default.
- W1580265037 hasConceptScore W1580265037C159047783 @default.
- W1580265037 hasConceptScore W1580265037C202751555 @default.
- W1580265037 hasConceptScore W1580265037C203014093 @default.
- W1580265037 hasConceptScore W1580265037C2522874641 @default.
- W1580265037 hasConceptScore W1580265037C2781196997 @default.
- W1580265037 hasConceptScore W1580265037C2908647359 @default.
- W1580265037 hasConceptScore W1580265037C2992881475 @default.
- W1580265037 hasConceptScore W1580265037C55493867 @default.
- W1580265037 hasConceptScore W1580265037C59822182 @default.
- W1580265037 hasConceptScore W1580265037C71924100 @default.
- W1580265037 hasConceptScore W1580265037C81444415 @default.
- W1580265037 hasConceptScore W1580265037C86803240 @default.
- W1580265037 hasConceptScore W1580265037C99454951 @default.
- W1580265037 hasIssue "5" @default.
- W1580265037 hasLocation W15802650371 @default.
- W1580265037 hasLocation W15802650372 @default.
- W1580265037 hasOpenAccess W1580265037 @default.
- W1580265037 hasPrimaryLocation W15802650371 @default.
- W1580265037 hasRelatedWork W1488891229 @default.
- W1580265037 hasRelatedWork W1513096311 @default.
- W1580265037 hasRelatedWork W1911571360 @default.
- W1580265037 hasRelatedWork W1976336311 @default.
- W1580265037 hasRelatedWork W2026890390 @default.
- W1580265037 hasRelatedWork W2050020144 @default.
- W1580265037 hasRelatedWork W2052483994 @default.
- W1580265037 hasRelatedWork W2055682819 @default.
- W1580265037 hasRelatedWork W2064759434 @default.
- W1580265037 hasRelatedWork W2074023757 @default.
- W1580265037 hasVolume "135" @default.
- W1580265037 isParatext "false" @default.
- W1580265037 isRetracted "false" @default.
- W1580265037 magId "1580265037" @default.
- W1580265037 workType "article" @default.