Matches in SemOpenAlex for { <https://semopenalex.org/work/W1580306383> ?p ?o ?g. }
- W1580306383 abstract "The use of inhibitors, both natural and synthetic has been a mainstay in the biochemical analysis of cellular pathways from glycolysis, the TCA cycle and the electron transport chain to DNA replication, cell signaling and apoptosis. With advents in screening technology, robotics and combinatorial chemistry, the field of chemical genetics was born. The development and use of small molecule inhibitors (SMIs) to modulate the activities of proteins has provided a wealth of knowledge on a variety of pathways and enhanced drug development targeting novel proteins and activities. The effectiveness of targeting enzymesubstrate interactions is well established and only more recently have protein-protein interactions been effectively targeted with SMIs (Saha et al., 2010; Huang et al., 2008; De et al., 2009; Ballatore et al., 2010; Yang et al., 2010; Weber, 2010). While targeting protein-DNA interactions has been considered by some to be “undrugable interactions” we and others have succeeded in developing SMIs capable of inhibiting these often complex interactions. The ability to develop inhibitors of protein-DNA complex formation capable of in vivo activity opens up an entire new class of targetable molecule interactions for potential therapeutic benefit. One could envision inhibiting proteins involved in transcription in addition to DNA replication, DNA repair and recombination. This review will summarize the recent successes in targeting protein-DNA interactions and draw the distinction between those agents that inhibit these interactions directly versus those that reduce protein-DNA interactions via indirect mechanisms. We also highlight the development of DNA repair inhibitors focusing on the clinical utility of targeting DNA repair for cancer therapy." @default.
- W1580306383 created "2016-06-24" @default.
- W1580306383 creator A5001081386 @default.
- W1580306383 creator A5005809670 @default.
- W1580306383 creator A5045603980 @default.
- W1580306383 creator A5062818460 @default.
- W1580306383 date "2011-10-26" @default.
- W1580306383 modified "2023-10-03" @default.
- W1580306383 title "Disruption of Protein–DNA Interactions: An Opportunity for Cancer Chemotherapy" @default.
- W1580306383 cites W1517823959 @default.
- W1580306383 cites W1886853229 @default.
- W1580306383 cites W1943783753 @default.
- W1580306383 cites W1945295084 @default.
- W1580306383 cites W1964702635 @default.
- W1580306383 cites W1972425323 @default.
- W1580306383 cites W1976400303 @default.
- W1580306383 cites W1982945504 @default.
- W1580306383 cites W1985086027 @default.
- W1580306383 cites W1987322786 @default.
- W1580306383 cites W1987698532 @default.
- W1580306383 cites W1997228454 @default.
- W1580306383 cites W1997356417 @default.
- W1580306383 cites W1997909925 @default.
- W1580306383 cites W1998031042 @default.
- W1580306383 cites W2000589976 @default.
- W1580306383 cites W2004029306 @default.
- W1580306383 cites W2004175299 @default.
- W1580306383 cites W2004695914 @default.
- W1580306383 cites W2005859121 @default.
- W1580306383 cites W2007208661 @default.
- W1580306383 cites W2007840001 @default.
- W1580306383 cites W2011120012 @default.
- W1580306383 cites W2014084740 @default.
- W1580306383 cites W2017715430 @default.
- W1580306383 cites W2024282024 @default.
- W1580306383 cites W2027441131 @default.
- W1580306383 cites W2028714796 @default.
- W1580306383 cites W2031793626 @default.
- W1580306383 cites W2041868573 @default.
- W1580306383 cites W2043892945 @default.
- W1580306383 cites W2043972688 @default.
- W1580306383 cites W2047470411 @default.
- W1580306383 cites W2050164541 @default.
- W1580306383 cites W2050567558 @default.
- W1580306383 cites W2050972063 @default.
- W1580306383 cites W2054348148 @default.
- W1580306383 cites W2058792197 @default.
- W1580306383 cites W2058807522 @default.
- W1580306383 cites W2059069220 @default.
- W1580306383 cites W2060763507 @default.
- W1580306383 cites W2062129127 @default.
- W1580306383 cites W2066171378 @default.
- W1580306383 cites W2066863961 @default.
- W1580306383 cites W2072471623 @default.
- W1580306383 cites W2073429728 @default.
- W1580306383 cites W2074356752 @default.
- W1580306383 cites W2078144380 @default.
- W1580306383 cites W2081161751 @default.
- W1580306383 cites W2083802827 @default.
- W1580306383 cites W2085948054 @default.
- W1580306383 cites W2086285137 @default.
- W1580306383 cites W2086715846 @default.
- W1580306383 cites W2093213682 @default.
- W1580306383 cites W2093986699 @default.
- W1580306383 cites W2094455441 @default.
- W1580306383 cites W2097826722 @default.
- W1580306383 cites W2099079381 @default.
- W1580306383 cites W2100457669 @default.
- W1580306383 cites W2101476607 @default.
- W1580306383 cites W2101988823 @default.
- W1580306383 cites W2103867015 @default.
- W1580306383 cites W2105901498 @default.
- W1580306383 cites W2108946761 @default.
- W1580306383 cites W2109306755 @default.
- W1580306383 cites W2113146796 @default.
- W1580306383 cites W2113230118 @default.
- W1580306383 cites W2113467423 @default.
- W1580306383 cites W2114114329 @default.
- W1580306383 cites W2117347104 @default.
- W1580306383 cites W2117525838 @default.
- W1580306383 cites W2117529142 @default.
- W1580306383 cites W2120000242 @default.
- W1580306383 cites W2121001769 @default.
- W1580306383 cites W2125519805 @default.
- W1580306383 cites W2125676993 @default.
- W1580306383 cites W2128457784 @default.
- W1580306383 cites W2129788206 @default.
- W1580306383 cites W2130266193 @default.
- W1580306383 cites W2130607828 @default.
- W1580306383 cites W2131670056 @default.
- W1580306383 cites W2132047377 @default.
- W1580306383 cites W2134661616 @default.
- W1580306383 cites W2134955541 @default.
- W1580306383 cites W2135763107 @default.
- W1580306383 cites W2139131914 @default.
- W1580306383 cites W2151513527 @default.
- W1580306383 cites W2153636865 @default.
- W1580306383 cites W2162325356 @default.
- W1580306383 cites W2165091409 @default.
- W1580306383 cites W2165385395 @default.