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- W1580395399 abstract "The solid Yoshida sarcoma in rats can be protected approximately twofold against the cytotoxicity of the alkylating agent melphalan if the animals are pretreated with cysteine. Using labelled melphalan it has been shown that in cysteine pretreated rats the uptake of the alkylating agent by the tumour is not affected but reaction with the nucleic acids and nuclear protein of the tumour is much reduced. In vitro experiments have shown that cysteine can prevent the reaction between melphalan and nucleic acids to the same extent as that occurring in vivo. A correlation has been shown between the reactivity of thiols in vitro towards melphalan and their ability to protect whole animals." @default.
- W1580395399 created "2016-06-24" @default.
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- W1580395399 date "1967-03-01" @default.
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- W1580395399 title "Reduction of the toxicity of “radiomimetic” alkylating agents by thiol pretreatment—VI" @default.
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- W1580395399 doi "https://doi.org/10.1016/0006-2952(67)90098-6" @default.
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