FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1580446023> ?p ?o ?g. }

• W1580446023 endingPage "1743" @default.
• W1580446023 startingPage "1736" @default.
• W1580446023 abstract "Complement plays a role in activating the inflammatory response and has been implicated in the pathogenesis of some inflammatory diseases. With a view toward controlling unwanted C activation, we evaluated the C regulator, human decay accelerating factor (DAF). Three forms of recombinant DAF were purified from transfected Chinese hamster ovary cells: glycophosphatidylinositol (GPI)-linked membrane DAF (mDAF) extracted from cell membranes; spontaneously shed soluble DAF (sDAF) derived from mDAF; and a novel secreted protein (seDAF), generated by deletion of the signal for GPI attachment. We show that all three molecules inhibit both the classical and alternative pathways of C activation. The following observations indicate that mDAF extracted from Chinese hamster ovary cells reincorporates into RBC membranes via its GPI anchor: 1) cells that are preincubated with mDAF and then washed remain fully protected from C-mediated hemolysis; 2) incubation with phosphatidylinositol-specific phospholipase C abolishes this protection; and 3) sDAF and seDAF, which lack a GPI anchor, do not associate with cell membranes. mDAF is a more potent inhibitor of C-mediated hemolysis than either sDAF or seDAF, suggesting that incorporation into cell membranes greatly enhances the efficiency with which DAF inhibits C activation on the cell surface. In contrast, C activation in the fluid phase is inhibited by sDAF and seDAF, but not by mDAF, possibly due to interference by serum lipoproteins. A reversed passive Arthus reaction in guinea pigs was used to evaluate the ability of recombinant seDAF to inhibit C activation in vivo. When administered at dermal sites, seDAF reduced the severity of immune complex-mediated inflammatory reactions induced by a reversed passive Arthus reaction, as judged by both gross and histologic examination. These data indicate that seDAF may be useful as an anti-inflammatory therapeutic." @default.
• W1580446023 created "2016-06-24" @default.
• W1580446023 creator A5011101907 @default.
• W1580446023 creator A5017616498 @default.
• W1580446023 creator A5021270337 @default.
• W1580446023 creator A5024318408 @default.
• W1580446023 creator A5027617639 @default.
• W1580446023 creator A5051447227 @default.
• W1580446023 creator A5070189703 @default.
• W1580446023 creator A5074122041 @default.
• W1580446023 creator A5074491067 @default.
• W1580446023 date "1992-09-01" @default.
• W1580446023 modified "2023-10-10" @default.
• W1580446023 title "Human recombinant soluble decay accelerating factor inhibits complement activation in vitro and in vivo." @default.
• W1580446023 doi "https://doi.org/10.4049/jimmunol.149.5.1736" @default.
• W1580446023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1380537" @default.
• W1580446023 hasPublicationYear "1992" @default.
• W1580446023 type Work @default.
• W1580446023 sameAs 1580446023 @default.
• W1580446023 citedByCount "80" @default.
• W1580446023 countsByYear W15804460232012 @default.
• W1580446023 countsByYear W15804460232013 @default.
• W1580446023 countsByYear W15804460232014 @default.
• W1580446023 countsByYear W15804460232015 @default.
• W1580446023 countsByYear W15804460232016 @default.
• W1580446023 countsByYear W15804460232017 @default.
• W1580446023 countsByYear W15804460232018 @default.
• W1580446023 countsByYear W15804460232022 @default.
• W1580446023 crossrefType "journal-article" @default.
• W1580446023 hasAuthorship W1580446023A5011101907 @default.
• W1580446023 hasAuthorship W1580446023A5017616498 @default.
• W1580446023 hasAuthorship W1580446023A5021270337 @default.
• W1580446023 hasAuthorship W1580446023A5024318408 @default.
• W1580446023 hasAuthorship W1580446023A5027617639 @default.
• W1580446023 hasAuthorship W1580446023A5051447227 @default.
• W1580446023 hasAuthorship W1580446023A5070189703 @default.
• W1580446023 hasAuthorship W1580446023A5074122041 @default.
• W1580446023 hasAuthorship W1580446023A5074491067 @default.
• W1580446023 hasBestOaLocation W15804460231 @default.
• W1580446023 hasConcept C104317684 @default.
• W1580446023 hasConcept C111684460 @default.
• W1580446023 hasConcept C1491633281 @default.
• W1580446023 hasConcept C150903083 @default.
• W1580446023 hasConcept C153911025 @default.
• W1580446023 hasConcept C159654299 @default.
• W1580446023 hasConcept C170493617 @default.
• W1580446023 hasConcept C175656101 @default.
• W1580446023 hasConcept C185592680 @default.
• W1580446023 hasConcept C189446657 @default.
• W1580446023 hasConcept C202751555 @default.
• W1580446023 hasConcept C203014093 @default.
• W1580446023 hasConcept C207001950 @default.
• W1580446023 hasConcept C2779902561 @default.
• W1580446023 hasConcept C40767141 @default.
• W1580446023 hasConcept C41625074 @default.
• W1580446023 hasConcept C55493867 @default.
• W1580446023 hasConcept C8487232 @default.
• W1580446023 hasConcept C86803240 @default.
• W1580446023 hasConcept C95444343 @default.
• W1580446023 hasConceptScore W1580446023C104317684 @default.
• W1580446023 hasConceptScore W1580446023C111684460 @default.
• W1580446023 hasConceptScore W1580446023C1491633281 @default.
• W1580446023 hasConceptScore W1580446023C150903083 @default.
• W1580446023 hasConceptScore W1580446023C153911025 @default.
• W1580446023 hasConceptScore W1580446023C159654299 @default.
• W1580446023 hasConceptScore W1580446023C170493617 @default.
• W1580446023 hasConceptScore W1580446023C175656101 @default.
• W1580446023 hasConceptScore W1580446023C185592680 @default.
• W1580446023 hasConceptScore W1580446023C189446657 @default.
• W1580446023 hasConceptScore W1580446023C202751555 @default.
• W1580446023 hasConceptScore W1580446023C203014093 @default.
• W1580446023 hasConceptScore W1580446023C207001950 @default.
• W1580446023 hasConceptScore W1580446023C2779902561 @default.
• W1580446023 hasConceptScore W1580446023C40767141 @default.
• W1580446023 hasConceptScore W1580446023C41625074 @default.
• W1580446023 hasConceptScore W1580446023C55493867 @default.
• W1580446023 hasConceptScore W1580446023C8487232 @default.
• W1580446023 hasConceptScore W1580446023C86803240 @default.
• W1580446023 hasConceptScore W1580446023C95444343 @default.
• W1580446023 hasIssue "5" @default.
• W1580446023 hasLocation W15804460231 @default.
• W1580446023 hasLocation W15804460232 @default.
• W1580446023 hasOpenAccess W1580446023 @default.
• W1580446023 hasPrimaryLocation W15804460231 @default.
• W1580446023 hasRelatedWork W1580446023 @default.
• W1580446023 hasRelatedWork W1777690075 @default.
• W1580446023 hasRelatedWork W1928671008 @default.
• W1580446023 hasRelatedWork W1983530931 @default.
• W1580446023 hasRelatedWork W2007823473 @default.
• W1580446023 hasRelatedWork W2033050894 @default.
• W1580446023 hasRelatedWork W2065130498 @default.
• W1580446023 hasRelatedWork W2127425255 @default.
• W1580446023 hasRelatedWork W2572121909 @default.
• W1580446023 hasRelatedWork W4229625553 @default.
• W1580446023 hasVolume "149" @default.
• W1580446023 isParatext "false" @default.
• W1580446023 isRetracted "false" @default.
• W1580446023 magId "1580446023" @default.

• next