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- W1580453558 abstract "Objective To investigate whether plasma omega-3 fatty acid (FA) concentrations (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA) modify the treatment effect of homocysteine-lowering B vitamins on brain atrophy rates and cognitive decline in a placebo-controlled trial. Design The effect of high-dose B vitamins in the previously reported VITACOG trial [PLoS ONE 5(9) 2010: e12244] was analysed according to baseline omega-3 FA concentrations. This study included 168 elderly (蠅70 y) with Mild Cognitive Impairment randomly assigned either to placebo, or to B vitamins. Results There was a significant interaction (P = 0.024) between B vitamin treatment and plasma combined omega-3 FA (EPA+DHA) on brain atrophy rates. In subjects with high baseline omega-3 FA (˃590 μmol/L), B-vitamin treatment slowed the mean atrophy rate by 40% compared with placebo (P = 0.023). B-vitamin treatment had no significant effect on rate of atrophy among subjects with low baseline omega-3 FA (<390 μmol/L). High baseline omega-3 FA were associated with a slower rate of brain atrophy in the B-vitamin group, but not in the placebo group. A similar interaction was found between omega-3 FA and the beneficial cognitive effects of B vitamin treatment. Conclusion The beneficial effect of B vitamin treatment on brain atrophy and cognitive decline was observed only in subjects with high plasma omega-3 FA. It is also suggested that the beneficial effect of omega-3 FA may be confined to subjects with good B vitamin status." @default.
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- W1580453558 date "2015-04-01" @default.
- W1580453558 modified "2023-09-23" @default.
- W1580453558 title "Omega‐3 Fatty Acids Modify Treatment Effect of High‐Dose B Vitamins in Cognitively Impaired Elderly" @default.
- W1580453558 doi "https://doi.org/10.1096/fasebj.29.1_supplement.401.1" @default.
- W1580453558 hasPublicationYear "2015" @default.
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