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• W1580490590 startingPage "2074" @default.
• W1580490590 abstract "ABSTRACT The Pseudomonas aeruginosa Mus clinical isolate produces OXA-18, a pI 5.5 class D extended-spectrum β-lactamase totally inhibited by clavulanic acid (L. N. Philippon, T. Naas, A.-T. Bouthors, V. Barakett, and P. Nordmann, Antimicrob. Agents Chemother. 41:2188–2195, 1997). A second β-lactamase was cloned, and the recombinant Escherichia coli clone pPL10 expressed a pI 7.4 β-lactamase which conferred high levels of amoxicillin and ticarcillin resistance and which was partially inhibited by clavulanic acid. The 2.5-kb insert from pPL10 was sequenced, and a 266-amino-acid protein (OXA-20) was deduced; this protein has low amino acid identity with most of the class D β-lactamases except OXA-2, OXA-15, and OXA-3 (75% amino acid identity with each). OXA-20 is a restricted-spectrum oxacillinase and is unusually inhibited by clavulanic acid. OXA-20 is a peculiar β-lactamase because its translation initiates with a TTG (leucine) codon, which is rarely used as a translational origin in bacteria. Exploration of the genetic environment of oxa20 revealed the presence of the following integron features: (i) a second antibiotic resistance gene, aacA4 ; (ii) an intI1 gene; and (iii) two 59-base elements, each associated with either oxa20 or aacA4 . This integron is peculiar because it lacks the 3′ conserved region, and therefore is not a sul1 -associated integron like most of them, and because its 3′ end is located within tnpR , a gene involved in the transposition of Tn 5393 , a gram-negative transposon. P. aeruginosa Mus produces two novel and unrelated oxacillinases, OXA-18 and OXA-20, both of which are inhibited by clavulanic acid." @default.
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• W1580490590 date "1998-08-01" @default.
• W1580490590 modified "2023-09-26" @default.
• W1580490590 title "Molecular Characterization of OXA-20, a Novel Class D β-Lactamase, and Its Integron from <i>Pseudomonas aeruginosa</i>" @default.
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• W1580490590 doi "https://doi.org/10.1128/aac.42.8.2074" @default.
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