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- W1580492821 abstract "Abstract Accumulation of primary Abs against two distinct epitopes on a designed polypeptide, MEP-1, was examined. The early primary response was predominantly against a C-terminal epitope (MEP 77-100), although subsequent maturation established an epitope within the N-terminal half (MEP 17-31) as the immunodominant one. Inversion of immunodominance correlated with the inability of anti-MEP 77-100 B cells to interact productively with T cells, which consequently received reduced help. Interaction between epitope-specific B and T cells was found to be attenuated in the presence of early primary anti-MEP-1 antiserum, and the extent of inhibition was directly proportional to the level and affinity of epitope-specific Igs. Therefore, it seems that early primary Abs to a multideterminant Ag selectively down-regulate maturation of epitope-specific primary humoral responses." @default.
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- W1580492821 date "1994-08-15" @default.
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- W1580492821 title "Antigen-specific early primary humoral responses modulate immunodominance of B cell epitopes." @default.
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- W1580492821 doi "https://doi.org/10.4049/jimmunol.153.4.1613" @default.
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