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- W158052039 abstract "Abstract Autoantibodies directed at tRNA related antigens are a feature of myositis, particularly in a syndrome of myositis with fibrosing alveolitis. Three antibodies, Jo-1, PL-7 and PL-12, inhibit the aminoacyl-tRNA synthetases for histidine, threonine and alanine, respectively. Jo-1 and PL-7 antibodies recognise a protein antigen (the enzyme) to which tRNA is bound, whereas the PL-12 specificity contains separate antibodies to alanyl-tRNA synthetase and tRNA (Ala). These findings are discussed in relation to the antigen-driven and anti-idiotype hypotheses of autoantibody formation." @default.
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- W158052039 date "1985-01-01" @default.
- W158052039 modified "2023-09-27" @default.
- W158052039 title "Autoantibodies to Transfer Rna-Related Antigens in Myositis" @default.
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- W158052039 doi "https://doi.org/10.1016/b978-0-08-033215-4.50085-6" @default.
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