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• W1580523544 abstract "Proc Amer Assoc Cancer Res, Volume 46, 20052553 Phytoestrogens have been hypothesised to lower breast cancer risk through stimulating sex hormone-binding globulin (SHBG) production and inhibiting enzymes involved in estrogen biosynthesis and metabolism, thus lowering levels of circulating estradiol. In this large cross-sectional study, we investigated the relationship between phytoestrogen exposure and plasma estradiol and SHBG levels in postmenopausal women and their relation with polymorphisms in relevant genes. Subjects consisted of 1743 free-living healthy postmenopausal women in the Norfolk arm of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. We have previously shown that urinary phytoestrogen levels correlated strongly with serum phytoestrogen levels (R=0.81 to 0.91, p<0.001) and can serve as suitable dietary biomarkers (1) . Urinary levels of 7 phytoestrogens (daidzein, genistein, glycitein, O-desmethylangolensin (O-DMA), equol, enterodiol and enterolactone) were analysed by liquid chromatography/tandem mass spectrometry and used as biomarkers for dietary phytoestrogen intake. Twelve single nucleotide polymorphisms (SNPs) in the COMT, CYP17, CYP19, EDH17B2, ESR1 and SHBG genes were genotyped using end-point Taqman assays. Plasma estradiol and SHBG were measured by immunoassays. Adjusting for age and body mass index, urinary O-DMA was positively correlated with plasma estradiol (R=0.050, p=0.037), with a stronger correlation found in the 487 women with TT genotype for ESR1 PvuII polymorphism (R= 0.133, p=0.003). The positive correlation observed in women as a whole became no longer significant when we excluded women with ESR1 PvuII TT genotype, indicating that the correlations observed were due mainly to this group of women. Adjusting for age and body mass index, urinary equol was negatively correlated with plasma estradiol (R= -0.060, p=0.013) and urinary enterolactone was positively correlated with plasma SHBG (R=0.110, p<0.001). Even in Western populations with low habitual soy consumption, phytoestrogen exposure exerts modest effects on plasma estradiol and SHBG levels in postmenopausal women and diet-gene interactions may be involved. Grant support: UK Medical Research Council, UK Food Standards Agency, Cancer Research UK and the Agency for Science, Technology and Research, Singapore . Reference 1. Grace PB, Taylor JI, Low Y-L, Luben RN, Mulligan A, Botting NP, et al. Phytoestrogen concentrations in serum and spot urine as biomarkers for dietary phytoestrogen intake and their relation to breast cancer risk in European Prospective Investigation of Cancer and Nutrition-Norfolk. Cancer Epidemiol Biomarkers Prev 2004;13:698-708." @default.
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• W1580523544 date "2005-05-01" @default.
• W1580523544 modified "2023-09-27" @default.
• W1580523544 title "Phytoestrogen exposure, polymorphisms in COMT, CYP17, CYP19, EDH17B2, ESR1 and SHBG genes and sex hormone levels among postmenopausal women in EPIC-Norfolk" @default.
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