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- W1580569750 endingPage "1699" @default.
- W1580569750 startingPage "1699" @default.
- W1580569750 abstract "Deficiencies in vitamins or other factors (B6, B12, folic acid, betaine) and genetic disorders for the metabolism of the non-protein amino acid-homocysteine (Hcy) lead to hyperhomocysteinemia (HHcy). HHcy is an integral component of several disorders including cardiovascular disease, neurodegeneration, diabetes and alcoholic liver disease. HHcy unleashes mediators of inflammation such as NFkappaB, IL-1beta, IL-6, and IL-8, increases production of intracellular superoxide anion causing oxidative stress and reducing intracellular level of nitric oxide (NO), and induces endoplasmic reticulum (ER) stress which can explain many processes of Hcy-promoted cell injury such as apoptosis, fat accumulation, and inflammation. Animal models have played an important role in determining the biological effects of HHcy. ER stress may also be involved in other liver diseases such as alpha (1)-antitrypsin (alpha(1)-AT) deficiency and hepatitis C and/or B virus infection. Future research should evaluate the possible potentiative effects of alcohol and hepatic virus infection on ER stress-induced liver injury, study potentially beneficial effects of lowering Hcy and preventing ER stress in alcoholic humans, and examine polymorphism of Hcy metabolizing enzymes as potential risk-factors for the development of HHcy and liver disease." @default.
- W1580569750 created "2016-06-24" @default.
- W1580569750 creator A5043356624 @default.
- W1580569750 creator A5059393102 @default.
- W1580569750 date "2004-01-01" @default.
- W1580569750 modified "2023-09-25" @default.
- W1580569750 title "Hyperhomocysteinemia, endoplasmic reticulum stress, and alcoholic liver injury" @default.
- W1580569750 cites W1486644147 @default.
- W1580569750 cites W1505269095 @default.
- W1580569750 cites W1549590649 @default.
- W1580569750 cites W1562522900 @default.
- W1580569750 cites W1565032730 @default.
- W1580569750 cites W1577460613 @default.
- W1580569750 cites W1583270829 @default.
- W1580569750 cites W178670659 @default.
- W1580569750 cites W181791200 @default.
- W1580569750 cites W1823550973 @default.
- W1580569750 cites W1846391066 @default.
- W1580569750 cites W1862022351 @default.
- W1580569750 cites W1878371608 @default.
- W1580569750 cites W1955583657 @default.
- W1580569750 cites W1963874291 @default.
- W1580569750 cites W1964635647 @default.
- W1580569750 cites W1965283476 @default.
- W1580569750 cites W1965772617 @default.
- W1580569750 cites W1966292733 @default.
- W1580569750 cites W1967842715 @default.
- W1580569750 cites W1970244956 @default.
- W1580569750 cites W1974207791 @default.
- W1580569750 cites W1978229870 @default.
- W1580569750 cites W1986987167 @default.
- W1580569750 cites W1988482079 @default.
- W1580569750 cites W1991958238 @default.
- W1580569750 cites W1994550739 @default.
- W1580569750 cites W1997329503 @default.
- W1580569750 cites W1997596609 @default.
- W1580569750 cites W1998785446 @default.
- W1580569750 cites W2002439304 @default.
- W1580569750 cites W2008258288 @default.
- W1580569750 cites W2008734149 @default.
- W1580569750 cites W2010981348 @default.
- W1580569750 cites W2011478745 @default.
- W1580569750 cites W2017564694 @default.
- W1580569750 cites W2018404966 @default.
- W1580569750 cites W2020649932 @default.
- W1580569750 cites W2020902432 @default.
- W1580569750 cites W2024428225 @default.
- W1580569750 cites W2025518316 @default.
- W1580569750 cites W2025850775 @default.
- W1580569750 cites W2031082846 @default.
- W1580569750 cites W2034810866 @default.
- W1580569750 cites W2035859053 @default.
- W1580569750 cites W2036481972 @default.
- W1580569750 cites W2038763220 @default.
- W1580569750 cites W2041553504 @default.
- W1580569750 cites W2043329777 @default.
- W1580569750 cites W2044766431 @default.
- W1580569750 cites W2045064670 @default.
- W1580569750 cites W2045642258 @default.
- W1580569750 cites W2048072799 @default.
- W1580569750 cites W2049511789 @default.
- W1580569750 cites W2050824645 @default.
- W1580569750 cites W2053535274 @default.
- W1580569750 cites W2054215652 @default.
- W1580569750 cites W2054601149 @default.
- W1580569750 cites W2054847530 @default.
- W1580569750 cites W2054876803 @default.
- W1580569750 cites W2055129444 @default.
- W1580569750 cites W2060388817 @default.
- W1580569750 cites W2062078580 @default.
- W1580569750 cites W2062378136 @default.
- W1580569750 cites W2062751582 @default.
- W1580569750 cites W2063347908 @default.
- W1580569750 cites W2064776807 @default.
- W1580569750 cites W2066688265 @default.
- W1580569750 cites W2067355567 @default.
- W1580569750 cites W2068485637 @default.
- W1580569750 cites W2069037942 @default.
- W1580569750 cites W2070563841 @default.
- W1580569750 cites W2072732992 @default.
- W1580569750 cites W2072879835 @default.
- W1580569750 cites W2079566392 @default.
- W1580569750 cites W2079604516 @default.
- W1580569750 cites W2080901528 @default.
- W1580569750 cites W2081078216 @default.
- W1580569750 cites W2083414623 @default.
- W1580569750 cites W2085452568 @default.
- W1580569750 cites W2085815287 @default.
- W1580569750 cites W2087355759 @default.
- W1580569750 cites W2090623873 @default.
- W1580569750 cites W2090839709 @default.
- W1580569750 cites W2093518775 @default.
- W1580569750 cites W2095199759 @default.
- W1580569750 cites W2096495868 @default.
- W1580569750 cites W2099386409 @default.
- W1580569750 cites W2104573407 @default.
- W1580569750 cites W2104985991 @default.
- W1580569750 cites W2106169918 @default.