FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1580762994> ?p ?o ?g. }

• W1580762994 endingPage "1972" @default.
• W1580762994 startingPage "1960" @default.
• W1580762994 abstract "Abstract We recently showed that oxytocin (OT) neurons in organotypic slice cultures obtained from postnatal rat hypothalamus display complex patterns of electrical activity, similar to those of adult magnocellular OT neurons in vivo. Here we used such cultures to investigate the identity and, in particular, the origin of afferent inputs responsible for this activity. Multiple immunostaining with light and confocal microscopy showed that the somata and dendrites of oxytocinergic neurons were contacted by numerous synapses, visualized by their reaction to the synaptic markers, synaptophysin or synapsin. Many were GABAergic, displaying immunoreactivities for glutamic acid decarboxylase or γ‐aminobutyric acid (GABA); others were enriched in glutamate immunoreactivity. Such afferents presumably arose from GABA‐ or glutamate‐immunoreactive neurons, respectively, with distinct and characteristic morphologies and topographies. A few dopaminergic boutons (tyrosine hydroxylase‐ or dopamine‐immunopositive) impinged on OT neurons; they arose from dopamine‐positive neurons located along the third ventricle. No noradrenergic profiles were detected. Despite the presence of choline acetyl‐transferase (ChAT)‐immunoreactive neurons, there were no cholinergic contacts. Lastly, we found oxytocinergic synapses, identified by immunoreaction for OT‐related neurophysin and synapsin, contacting OT somata and dendrites. Our observations thus demonstrate that inhibitory and excitatory inputs to OT neurons derive from local intrahypothalamic GABA and glutamate neurons, in close proximity to the neurons. They also reveal that OT neurons are innervated by hypothalamic dopaminergic neurons. Finally, they confirm the existence of homotypic OT synaptic contacts which derive from local OT neurons." @default.
• W1580762994 created "2016-06-24" @default.
• W1580762994 creator A5040078560 @default.
• W1580762994 creator A5054489600 @default.
• W1580762994 creator A5059753318 @default.
• W1580762994 creator A5067398092 @default.
• W1580762994 creator A5077297412 @default.
• W1580762994 creator A5079426300 @default.
• W1580762994 date "1999-06-01" @default.
• W1580762994 modified "2023-10-17" @default.
• W1580762994 title "Visualization of local afferent inputs to magnocellular oxytocin neurons in vitro" @default.
• W1580762994 cites W1559933348 @default.
• W1580762994 cites W1916585012 @default.
• W1580762994 cites W1958860054 @default.
• W1580762994 cites W1972146659 @default.
• W1580762994 cites W1977615449 @default.
• W1580762994 cites W1978044599 @default.
• W1580762994 cites W1979091546 @default.
• W1580762994 cites W1984237289 @default.
• W1580762994 cites W2009178283 @default.
• W1580762994 cites W2014544605 @default.
• W1580762994 cites W2015986915 @default.
• W1580762994 cites W2021318937 @default.
• W1580762994 cites W2021717626 @default.
• W1580762994 cites W2025936573 @default.
• W1580762994 cites W2029624481 @default.
• W1580762994 cites W2030677119 @default.
• W1580762994 cites W2035547459 @default.
• W1580762994 cites W2038430188 @default.
• W1580762994 cites W2046973221 @default.
• W1580762994 cites W2047723877 @default.
• W1580762994 cites W2052184070 @default.
• W1580762994 cites W2054134853 @default.
• W1580762994 cites W2061762896 @default.
• W1580762994 cites W2062346821 @default.
• W1580762994 cites W2064148637 @default.
• W1580762994 cites W2067467155 @default.
• W1580762994 cites W2068434967 @default.
• W1580762994 cites W2068701782 @default.
• W1580762994 cites W2070835185 @default.
• W1580762994 cites W2072048191 @default.
• W1580762994 cites W2074194239 @default.
• W1580762994 cites W2077944067 @default.
• W1580762994 cites W2081130032 @default.
• W1580762994 cites W2084785448 @default.
• W1580762994 cites W2089750332 @default.
• W1580762994 cites W2094051674 @default.
• W1580762994 cites W2094687206 @default.
• W1580762994 cites W2098099800 @default.
• W1580762994 cites W2109082652 @default.
• W1580762994 cites W2119677102 @default.
• W1580762994 cites W2126473406 @default.
• W1580762994 cites W2129340317 @default.
• W1580762994 cites W2135472547 @default.
• W1580762994 cites W2135977529 @default.
• W1580762994 cites W2168650408 @default.
• W1580762994 cites W2252415710 @default.
• W1580762994 cites W2317667639 @default.
• W1580762994 cites W2324544382 @default.
• W1580762994 cites W2423253222 @default.
• W1580762994 cites W30214547 @default.
• W1580762994 cites W4233126096 @default.
• W1580762994 cites W4293775882 @default.
• W1580762994 doi "https://doi.org/10.1046/j.1460-9568.1999.00620.x" @default.
• W1580762994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10336665" @default.
• W1580762994 hasPublicationYear "1999" @default.
• W1580762994 type Work @default.
• W1580762994 sameAs 1580762994 @default.
• W1580762994 citedByCount "46" @default.
• W1580762994 countsByYear W15807629942014 @default.
• W1580762994 countsByYear W15807629942015 @default.
• W1580762994 countsByYear W15807629942017 @default.
• W1580762994 countsByYear W15807629942018 @default.
• W1580762994 crossrefType "journal-article" @default.
• W1580762994 hasAuthorship W1580762994A5040078560 @default.
• W1580762994 hasAuthorship W1580762994A5054489600 @default.
• W1580762994 hasAuthorship W1580762994A5059753318 @default.
• W1580762994 hasAuthorship W1580762994A5067398092 @default.
• W1580762994 hasAuthorship W1580762994A5077297412 @default.
• W1580762994 hasAuthorship W1580762994A5079426300 @default.
• W1580762994 hasConcept C103072069 @default.
• W1580762994 hasConcept C112592302 @default.
• W1580762994 hasConcept C130316041 @default.
• W1580762994 hasConcept C137183658 @default.
• W1580762994 hasConcept C148785051 @default.
• W1580762994 hasConcept C169760540 @default.
• W1580762994 hasConcept C170493617 @default.
• W1580762994 hasConcept C17077164 @default.
• W1580762994 hasConcept C181199279 @default.
• W1580762994 hasConcept C21158919 @default.
• W1580762994 hasConcept C2776176026 @default.
• W1580762994 hasConcept C2779177108 @default.
• W1580762994 hasConcept C41625074 @default.
• W1580762994 hasConcept C50493954 @default.
• W1580762994 hasConcept C513476851 @default.
• W1580762994 hasConcept C54355233 @default.
• W1580762994 hasConcept C55493867 @default.
• W1580762994 hasConcept C61174792 @default.

• next