FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1580786546> ?p ?o ?g. }

• W1580786546 endingPage "40" @default.
• W1580786546 startingPage "25" @default.
• W1580786546 abstract "Paraquat (PQ; 1, 1′-dimethyl-4-4′-bipyridinium), an herbicide and model neurotoxicant, is identified to be one of the prime risk factors in Parkinson's disease (PD). In the Drosophila system, PQ is commonly used to measure acquired resistance against oxidative stress (PQ resistance test). Despite this, under acute PQ exposure, data on the oxidative stress response and associated impact on mitochondria among flies is limited. Accordingly, in this study, we measured markers of oxidative stress and mitochondrial dysfunctions among adult male flies (8–10 days old) exposed to varying concentrations of PQ (10, 20, and 40 mM in 5% sucrose solution) employing a conventional filter disc method for 24 h. PQ exposure resulted in significant elevation in the levels of oxidative stress biomarkers (malondialdehyde: 43% increase: hydroperoxide: 32–39% increase), with concomitant enhancement in reduced glutathione and total thiol levels in cytosol. Higher activity of antioxidant enzymes were also evident along with increased free iron levels. Furthermore, PQ exposure caused a concentration-dependent increase in mitochondrial superoxide generation and activity of manganese-superoxide dismutase (Mn-SOD). The activity levels of complex I-III, complex II-III, and Mg+2 adinosine triphosphatase (ATPase) were also decreased significantly. A robust diminution in the activity of succinate dehydrogenase and moderate decline in the citrate synthase activity suggested a specific effect on citric acid cycle enzymes. Collectively, these data suggest that acute PQ exposure causes significant oxidative stress and mitochondrial dysfunction among flies in vivo. It is suggested that in various experimental settings, while conducting the “PQ resistance stress test” incorporation of selected biochemical end points is likely to enhance the quality of the data." @default.
• W1580786546 created "2016-06-24" @default.
• W1580786546 creator A5046737585 @default.
• W1580786546 creator A5078831541 @default.
• W1580786546 date "2013-04-05" @default.
• W1580786546 modified "2023-10-18" @default.
• W1580786546 title "ACUTE EXPOSURE OF<i>Drosophila melanogaster</i>TO PARAQUAT CAUSES OXIDATIVE STRESS AND MITOCHONDRIAL DYSFUNCTION" @default.
• W1580786546 cites W1135627251 @default.
• W1580786546 cites W1451660614 @default.
• W1580786546 cites W1523119366 @default.
• W1580786546 cites W1644794975 @default.
• W1580786546 cites W1792892656 @default.
• W1580786546 cites W1846128798 @default.
• W1580786546 cites W191793640 @default.
• W1580786546 cites W1966699971 @default.
• W1580786546 cites W1971048984 @default.
• W1580786546 cites W1971389338 @default.
• W1580786546 cites W1976202841 @default.
• W1580786546 cites W1982563082 @default.
• W1580786546 cites W1984002924 @default.
• W1580786546 cites W1984304489 @default.
• W1580786546 cites W1987266879 @default.
• W1580786546 cites W1998924477 @default.
• W1580786546 cites W2000510440 @default.
• W1580786546 cites W2002017682 @default.
• W1580786546 cites W2002940154 @default.
• W1580786546 cites W2003955840 @default.
• W1580786546 cites W2007658546 @default.
• W1580786546 cites W2019817056 @default.
• W1580786546 cites W2022361791 @default.
• W1580786546 cites W2025716620 @default.
• W1580786546 cites W2028739456 @default.
• W1580786546 cites W2030134419 @default.
• W1580786546 cites W2031172417 @default.
• W1580786546 cites W2031683219 @default.
• W1580786546 cites W2049207446 @default.
• W1580786546 cites W2049858503 @default.
• W1580786546 cites W2053796870 @default.
• W1580786546 cites W2054337650 @default.
• W1580786546 cites W2062088744 @default.
• W1580786546 cites W2071392807 @default.
• W1580786546 cites W2072615530 @default.
• W1580786546 cites W2074957501 @default.
• W1580786546 cites W2077346129 @default.
• W1580786546 cites W2085210335 @default.
• W1580786546 cites W2093690905 @default.
• W1580786546 cites W2099576328 @default.
• W1580786546 cites W2122032354 @default.
• W1580786546 cites W2136372622 @default.
• W1580786546 cites W2153023878 @default.
• W1580786546 cites W954944586 @default.
• W1580786546 doi "https://doi.org/10.1002/arch.21094" @default.
• W1580786546 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23564607" @default.
• W1580786546 hasPublicationYear "2013" @default.
• W1580786546 type Work @default.
• W1580786546 sameAs 1580786546 @default.
• W1580786546 citedByCount "88" @default.
• W1580786546 countsByYear W15807865462013 @default.
• W1580786546 countsByYear W15807865462014 @default.
• W1580786546 countsByYear W15807865462015 @default.
• W1580786546 countsByYear W15807865462016 @default.
• W1580786546 countsByYear W15807865462017 @default.
• W1580786546 countsByYear W15807865462018 @default.
• W1580786546 countsByYear W15807865462019 @default.
• W1580786546 countsByYear W15807865462020 @default.
• W1580786546 countsByYear W15807865462021 @default.
• W1580786546 countsByYear W15807865462022 @default.
• W1580786546 countsByYear W15807865462023 @default.
• W1580786546 crossrefType "journal-article" @default.
• W1580786546 hasAuthorship W1580786546A5046737585 @default.
• W1580786546 hasAuthorship W1580786546A5078831541 @default.
• W1580786546 hasConcept C181199279 @default.
• W1580786546 hasConcept C2775838275 @default.
• W1580786546 hasConcept C2776151105 @default.
• W1580786546 hasConcept C2776527163 @default.
• W1580786546 hasConcept C2778004101 @default.
• W1580786546 hasConcept C2778401633 @default.
• W1580786546 hasConcept C28859421 @default.
• W1580786546 hasConcept C48349386 @default.
• W1580786546 hasConcept C538909803 @default.
• W1580786546 hasConcept C55493867 @default.
• W1580786546 hasConcept C57600042 @default.
• W1580786546 hasConcept C86803240 @default.
• W1580786546 hasConceptScore W1580786546C181199279 @default.
• W1580786546 hasConceptScore W1580786546C2775838275 @default.
• W1580786546 hasConceptScore W1580786546C2776151105 @default.
• W1580786546 hasConceptScore W1580786546C2776527163 @default.
• W1580786546 hasConceptScore W1580786546C2778004101 @default.
• W1580786546 hasConceptScore W1580786546C2778401633 @default.
• W1580786546 hasConceptScore W1580786546C28859421 @default.
• W1580786546 hasConceptScore W1580786546C48349386 @default.
• W1580786546 hasConceptScore W1580786546C538909803 @default.
• W1580786546 hasConceptScore W1580786546C55493867 @default.
• W1580786546 hasConceptScore W1580786546C57600042 @default.
• W1580786546 hasConceptScore W1580786546C86803240 @default.
• W1580786546 hasIssue "1" @default.
• W1580786546 hasLocation W15807865461 @default.
• W1580786546 hasLocation W15807865462 @default.

• next