FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1580929162> ?p ?o ?g. }

• W1580929162 endingPage "2965" @default.
• W1580929162 startingPage "2947" @default.
• W1580929162 abstract "Ciliary neurotrophic factor (CNTF) administration maintains, protects, and promotes the regeneration of both motor neurons (MNs) and skeletal muscle in a wide variety of models. Expression of CNTF receptor α (CNTFRα), an essential CNTF receptor component, is greatly increased in skeletal muscle following neuromuscular insult. Together the data suggest that muscle CNTFRα may contribute to neuromuscular maintenance, protection, and/or regeneration in vivo. To directly address the role of muscle CNTFRα, we selectively-depleted it in vivo by using a “floxed” CNTFRα mouse line and a gene construct (mlc1f-Cre) that drives the expression of Cre specifically in skeletal muscle. The resulting mice were challenged with sciatic nerve crush. Counting of nerve axons and retrograde tracing of MNs indicated that muscle CNTFRα contributes to MN axonal regeneration across the lesion site. Walking track analysis indicated that muscle CNTFRα is also required for normal recovery of motor function. However, the same muscle CNTFRα depletion unexpectedly had no detected effect on the maintenance or regeneration of the muscle itself, even though exogenous CNTF has been shown to affect these functions. Similarly, MN survival and lesion-induced terminal sprouting were unaffected. Therefore, muscle CNTFRα is an interesting new example of a muscle growth factor receptor that, in vivo under physiological conditions, contributes much more to neuronal regeneration than to the maintenance or regeneration of the muscle itself. This novel form of muscle–neuron interaction also has implications in the therapeutic targeting of the neuromuscular system in MN disorders and following nerve injury. J. Comp. Neurol. 521: 2947–2965, 2013. © 2013 Wiley Periodicals, Inc." @default.
• W1580929162 created "2016-06-24" @default.
• W1580929162 creator A5010753917 @default.
• W1580929162 creator A5011165365 @default.
• W1580929162 creator A5024216842 @default.
• W1580929162 creator A5040120058 @default.
• W1580929162 creator A5041401010 @default.
• W1580929162 creator A5043363192 @default.
• W1580929162 creator A5046617512 @default.
• W1580929162 creator A5052113690 @default.
• W1580929162 creator A5061039999 @default.
• W1580929162 creator A5075884320 @default.
• W1580929162 date "2013-07-17" @default.
• W1580929162 modified "2023-10-14" @default.
• W1580929162 title "Muscle ciliary neurotrophic factor receptor α promotes axonal regeneration and functional recovery following peripheral nerve lesion" @default.
• W1580929162 cites W1530725542 @default.
• W1580929162 cites W1768274470 @default.
• W1580929162 cites W1865290313 @default.
• W1580929162 cites W1908834838 @default.
• W1580929162 cites W1963853740 @default.
• W1580929162 cites W1970819272 @default.
• W1580929162 cites W1972681625 @default.
• W1580929162 cites W1976623895 @default.
• W1580929162 cites W1980924577 @default.
• W1580929162 cites W1984325317 @default.
• W1580929162 cites W1985933922 @default.
• W1580929162 cites W1990590034 @default.
• W1580929162 cites W1994685485 @default.
• W1580929162 cites W1995735247 @default.
• W1580929162 cites W1999048005 @default.
• W1580929162 cites W2000738691 @default.
• W1580929162 cites W2003680403 @default.
• W1580929162 cites W2008443890 @default.
• W1580929162 cites W2011307895 @default.
• W1580929162 cites W2011640487 @default.
• W1580929162 cites W2014660851 @default.
• W1580929162 cites W2016349752 @default.
• W1580929162 cites W2021054927 @default.
• W1580929162 cites W2022170014 @default.
• W1580929162 cites W2025199687 @default.
• W1580929162 cites W2029573581 @default.
• W1580929162 cites W2032298845 @default.
• W1580929162 cites W2036351079 @default.
• W1580929162 cites W2036746321 @default.
• W1580929162 cites W2040279236 @default.
• W1580929162 cites W2043967275 @default.
• W1580929162 cites W2046739492 @default.
• W1580929162 cites W2047380710 @default.
• W1580929162 cites W2049689731 @default.
• W1580929162 cites W2052027207 @default.
• W1580929162 cites W2053791094 @default.
• W1580929162 cites W2055766536 @default.
• W1580929162 cites W2057581648 @default.
• W1580929162 cites W2060359654 @default.
• W1580929162 cites W2060569257 @default.
• W1580929162 cites W2063906922 @default.
• W1580929162 cites W2070720564 @default.
• W1580929162 cites W2076608010 @default.
• W1580929162 cites W2081082633 @default.
• W1580929162 cites W2082442359 @default.
• W1580929162 cites W2082995803 @default.
• W1580929162 cites W2083250868 @default.
• W1580929162 cites W2090097165 @default.
• W1580929162 cites W2092312715 @default.
• W1580929162 cites W2096158110 @default.
• W1580929162 cites W2099344864 @default.
• W1580929162 cites W2100327009 @default.
• W1580929162 cites W2109713397 @default.
• W1580929162 cites W2109918184 @default.
• W1580929162 cites W2116654149 @default.
• W1580929162 cites W2126739765 @default.
• W1580929162 cites W2127810309 @default.
• W1580929162 cites W2128140485 @default.
• W1580929162 cites W2135601375 @default.
• W1580929162 cites W2143550055 @default.
• W1580929162 cites W2147121352 @default.
• W1580929162 cites W2148240710 @default.
• W1580929162 cites W2152890178 @default.
• W1580929162 cites W2156316410 @default.
• W1580929162 cites W2164503423 @default.
• W1580929162 cites W2166670696 @default.
• W1580929162 cites W2170178615 @default.
• W1580929162 cites W2187068790 @default.
• W1580929162 cites W2355345 @default.
• W1580929162 cites W4239418442 @default.
• W1580929162 cites W4240083082 @default.
• W1580929162 cites W4246151551 @default.
• W1580929162 cites W4300634487 @default.
• W1580929162 doi "https://doi.org/10.1002/cne.23324" @default.
• W1580929162 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3992866" @default.
• W1580929162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23504871" @default.
• W1580929162 hasPublicationYear "2013" @default.
• W1580929162 type Work @default.
• W1580929162 sameAs 1580929162 @default.
• W1580929162 citedByCount "12" @default.
• W1580929162 countsByYear W15809291622014 @default.
• W1580929162 countsByYear W15809291622015 @default.
• W1580929162 countsByYear W15809291622016 @default.

• next