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- W1581002015 abstract "Human cancer is characterized by a process of tumor cell motility, invasion, and metastasis. One of the critical tyrosine kinases that is linked to these processes of tumor invasion and survival is the Focal Adhesion Kinase (FAK). Our laboratory was the first to isolate FAK from human tumors, and we had demonstrated that FAK mRNA was up-regulated in invasive and metastatic human breast and colon cancer samples. We have cloned FAK promoter and have found that FAK promoter contains p53 binding sites, and that p53 inhibits FAK transcription and regulates its expression in tumor samples. In addition, we have found a high correlation between FAK overexpression and p53 mutations in 600 population-based series of breast cancer patients. found that N-myc binds FAK promoter and induces FAK transcription in neuroblastoma cells. Thus, this review will be focused on FAK and p53 signal transduction pathways in cancer." @default.
- W1581002015 created "2016-06-24" @default.
- W1581002015 creator A5024475539 @default.
- W1581002015 creator A5059982950 @default.
- W1581002015 date "2010-01-01" @default.
- W1581002015 modified "2023-10-15" @default.
- W1581002015 title "Focal adhesion kinase and p53 signal transduction pathways in cancer" @default.
- W1581002015 cites W1430273632 @default.
- W1581002015 cites W1524238275 @default.
- W1581002015 cites W1525249836 @default.
- W1581002015 cites W1532590486 @default.
- W1581002015 cites W1580151046 @default.
- W1581002015 cites W1785533687 @default.
- W1581002015 cites W1929023701 @default.
- W1581002015 cites W1931127206 @default.
- W1581002015 cites W1964020745 @default.
- W1581002015 cites W1964224010 @default.
- W1581002015 cites W1965363596 @default.
- W1581002015 cites W1967117930 @default.
- W1581002015 cites W1967880683 @default.
- W1581002015 cites W1968750755 @default.
- W1581002015 cites W1969342647 @default.
- W1581002015 cites W1969820174 @default.
- W1581002015 cites W1970131417 @default.
- W1581002015 cites W1970228357 @default.
- W1581002015 cites W1973118819 @default.
- W1581002015 cites W1974215052 @default.
- W1581002015 cites W1975634056 @default.
- W1581002015 cites W1975866732 @default.
- W1581002015 cites W1977426071 @default.
- W1581002015 cites W1979452780 @default.
- W1581002015 cites W1979757399 @default.
- W1581002015 cites W1980891354 @default.
- W1581002015 cites W1981393628 @default.
- W1581002015 cites W1981462495 @default.
- W1581002015 cites W1984947728 @default.
- W1581002015 cites W1985961293 @default.
- W1581002015 cites W1987213235 @default.
- W1581002015 cites W1987278872 @default.
- W1581002015 cites W1988664861 @default.
- W1581002015 cites W1989219613 @default.
- W1581002015 cites W1991494214 @default.
- W1581002015 cites W1992546098 @default.
- W1581002015 cites W1993282257 @default.
- W1581002015 cites W1999247203 @default.
- W1581002015 cites W2000403420 @default.
- W1581002015 cites W2000983089 @default.
- W1581002015 cites W2001258296 @default.
- W1581002015 cites W2006145157 @default.
- W1581002015 cites W2006834821 @default.
- W1581002015 cites W2007010211 @default.
- W1581002015 cites W2009813647 @default.
- W1581002015 cites W2009871049 @default.
- W1581002015 cites W2013928497 @default.
- W1581002015 cites W2017513981 @default.
- W1581002015 cites W2018554367 @default.
- W1581002015 cites W2020121459 @default.
- W1581002015 cites W2021064989 @default.
- W1581002015 cites W2022167872 @default.
- W1581002015 cites W2025018535 @default.
- W1581002015 cites W2025618547 @default.
- W1581002015 cites W2027186413 @default.
- W1581002015 cites W2028211858 @default.
- W1581002015 cites W2028691987 @default.
- W1581002015 cites W2031994938 @default.
- W1581002015 cites W2036145275 @default.
- W1581002015 cites W2037195684 @default.
- W1581002015 cites W2038658205 @default.
- W1581002015 cites W2041200273 @default.
- W1581002015 cites W2041563661 @default.
- W1581002015 cites W2059407064 @default.
- W1581002015 cites W2063158632 @default.
- W1581002015 cites W2063277829 @default.
- W1581002015 cites W2065088072 @default.
- W1581002015 cites W2065611313 @default.
- W1581002015 cites W2068540074 @default.
- W1581002015 cites W2070460007 @default.
- W1581002015 cites W2072290112 @default.
- W1581002015 cites W2072564410 @default.
- W1581002015 cites W2072583244 @default.
- W1581002015 cites W2075505867 @default.
- W1581002015 cites W2076457965 @default.
- W1581002015 cites W2082293650 @default.
- W1581002015 cites W2083309399 @default.
- W1581002015 cites W2084510672 @default.
- W1581002015 cites W2091506455 @default.
- W1581002015 cites W2094147757 @default.
- W1581002015 cites W2105356859 @default.
- W1581002015 cites W2106415445 @default.
- W1581002015 cites W2107200488 @default.
- W1581002015 cites W2107379927 @default.
- W1581002015 cites W2110161012 @default.
- W1581002015 cites W2111163639 @default.
- W1581002015 cites W2113912964 @default.
- W1581002015 cites W2118105104 @default.
- W1581002015 cites W2122381944 @default.
- W1581002015 cites W2126708001 @default.
- W1581002015 cites W2139458393 @default.