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- W1581152815 abstract "OBJECTIVE: Although the ketogenic diet (KD) is effective in approximately 50% of children with refractory epilepsy, some children on the diet are not fully controlled. In these situations, doctors often begin “fine-tuning” the KD.DESIGN/METHODS: A retrospective chart review was performed of 200 children that started the KD at Johns Hopkins Hospital between October 2007 and June 2013. Ten dietary/supplement changes were identified as the most commonly implemented. Medication adjustments were also reviewed. Patient records were reviewed over the entire KD duration up to a maximum of 4 interventions per child. Success was defined as a documentation of >50% seizure reduction after a change.RESULTS: The majority, 156 (78%), had at least one intervention. A total of 391 distinct and occasionally concurrent interventions occurred, of which 265 were made specifically for seizure control. Overall, there was an 18% chance that any intervention would be successful, but only a 3% chance of resultant seizure freedom. The likelihood of success did not decrease with each subsequent intervention (p=.44). There was a trend towards medication adjustments being more successful than dietary modifications (24% vs. 15%, p = 0.08). Of the dietary adjustments, no one modification stood out as the most effective in achieving seizure control.CONCLUSIONS: These findings suggest that fine-tuning the KD is helpful in approximately 1 in 5, even after 12 months of use. Medication adjustment and dietary modification lead to similar outcomes, therefore both can be tried if the KD is not meeting seizure control expectations.Study Supported by: AAN Medical Student Summer Research Scholarship Disclosure: Dr. Selter has nothing to disclose. Dr. Turner has nothing to disclose. Dr. Doerrer has nothing to disclose. Dr. Kossoff has received personal compensation for activities with Atkins Nutritionals, Inc. and Eisai, Inc. as a scientific advisory board member. Dr. Kossoff has received research support from Nutricia, Inc." @default.
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- W1581152815 date "2014-04-08" @default.
- W1581152815 modified "2023-09-24" @default.
- W1581152815 title "Can You Fine Tune the Ketogenic Diet (P4.323)" @default.
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