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• W1581161429 abstract "Abstract Aryl hydrocarbon hydroxylase induction in fetal rat liver cells in culture by phenobarbital or 3-methylcholanthrene proceeds just as well in 10% heat-inactivated, boiled, or dialyzed calf serum as in regular 10% calf serum in the growth medium. After the hepatocytes are attached, the serum-containing medium can be replaced with serum-free, completely defined medium for several days, so that the influence of various hormones or other endogenous compounds on the basal and inducible hydroxylase activities can be evaluated. Significant stimulatory effects are produced by testosterone, glucagon, and prostaglandins; significant decreases are seen with 17-β-estradiol, insulin, and dexamethasone. No significant effects are found with adrenocorticotropic hormone, human growth hormone, thyroxine, prolactin, derivatives of cyclic adenosine 3',5'-monophosphate, and numerous other endogenous compounds such as fatty acids and alkyl polyamines, alone and in combinations. The kinetics of aryl hydrocarbon hydroxylase induction by 1.0 mm norepinephrine or by other biogenic amines of similar structure is the same as that by phenobarbital or 3-methylcholanthrene. The effects of phenobarbital, 3-methylcholanthrene, and biogenic amines with either a phenyl or indolen ucleus on the hydroxylase induction are additive or synergistic when two or three of these types of inducers are combined in the culture medium. From the use of an aromatic l-amino acid decarboxylase inhibitor and a monoamine oxidase inhibitor added prior to the biogenic amines, we conclude that the amine, rather than any metabolite, is directly involved in causing hydroxylase induction. The effect of norepinephrine is greater than that of phenobarbital or 3-methylcholanthrene in retarding the normal rate of degradation of induced hydroxylase activity in the presence or the absence of protein synthesis. Either phenobarbital or 3-methylcholanthrene or norepinephrine as a second inducer can direct at some posttranscriptional level a further rise in hydroxylase activity after treatment of the hepatocytes with the first inducer." @default.
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• W1581161429 date "1972-12-01" @default.
• W1581161429 modified "2023-09-30" @default.
• W1581161429 title "Aryl Hydrocarbon Hydroxylase Induction in Mammalian Liver Cell Culture" @default.
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• W1581161429 doi "https://doi.org/10.1016/s0021-9258(19)44566-3" @default.
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